Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands
スポンサーリンク
概要
- 論文の詳細を見る
Signaling via hepatocyte growth factor (HGF) and the HGF receptor, c-Met, plays important roles in human salivary glands and salivary gland tumors. Various effects of HGF, including acceleration or inhibition of cell growth, enhancement of cell motility, increase of angiogenesis, inhibition of apoptosis and induction of morphogenesis, have been demonstrated in various epithelial cells. Our recent analysis of HGF regarding saliva, salivary gland and salivary gland tumors demonstrated that : 1) HGF was basically localized in luminal cells of fetal, normal salivary glands and salivary gland tumors ; 2) saliva contained HGF protein on ELISA ; 3) HGF tended to be more intensely expressed in benign salivary gland tumors than in malignant salivary gland tumors ; 4) HGF/c-Met signaling was associated with cell scattering and invasion into matrix in the ACC3 adenoid cystic carcinoma cell line ; 5) prognosis was poor and correlated to metastasis in high-grade salivary gland carcinomas with c-Met overexpression. These profiles suggest that HGF/c-Met systems may play significant roles in differentiation or tumor progression for salivary gland tumors.
- 日本組織細胞化学会の論文
著者
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Osamura Robert
Department of Pathology, Tokai University School of Medicine
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Yasuda Masanori
Department of Pathology, Saitama Medical University International Medical Center
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Osamura R
Department Of Pathology Tokai University School Of Medicine
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MORI Yusuke
Department of Engineering, Osaka University
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Osamura R.yoshiyuki
東海大学 医学研究科病理病態学
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Osamura Yoshiyuki
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学 医学部病理診断学
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Osamura R
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学教育･研究支援センター
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Osamura Robert
Dep. Of Pathology Tokai Univ. School Of Medicine
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Mori Yusuke
Department Of Electrical Engineering Osaka University
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Kaneko Akihiro
Department Of Oral Surgery Tokai University School Of Medicine
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WATANABE Yoshihisa
Department of Surgery, Division II, Kobe University School of Medicine
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Tsukinoki Keiichi
Department of Pathology, Kanagawa Dental College
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Miyoshi Yoshiko
Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College
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Otsuru Mitsunobu
Department of Oral Surgery, Tokai University School of Medicine
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Saruta Juri
Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College
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Sato Sadao
Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College
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Yasuda M
Department Of Pathology Tokai University School Of Medicine
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Yasuda Masanori
Department Of Pathology School Of Medicine Tokai University
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Yasuda Masanori
Departments Of Pathology Tokai University School Of Medicine
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Watanabe Yoshihisa
Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College
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Osamura R
Tokai Univ. School Of Medicine Kanagawa Jpn
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Osamura R.yoshiyuki
Department Of Pathology Tokai University School Of Medicine
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Sato Sadao
Department Of Craniofacial Growth And Development Dentistry Kanagawa Dental College
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Saruta Juri
Department Of Craniofacial Growth And Development Dentistry Kanagawa Dental College
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Osamura Robert
Department Of Pathology School Of Medicine Tokai University
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Otsuru Mitsunobu
Department Of Oral Surgery Tokai University School Of Medicine
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Kaneko Akihiro
Department Of Oral Surgery School Of Medicine Tokai University
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Watanabe Y
Department Of Oral Pathology Kanagawa Dental College
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Osamura R.
Tokai Univ. School Of Medicine Kanagawa Jpn
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Yamazaki Michio
Department Of Pathology Saitama Medical University International Medical Center
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Otsuru Mitsunobu
Department Of Oral And Maxillofacial Surgery Tokai University School Of Medicine
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Osamura R
Tokai Univ. School Of Medicine
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Mizoguchi Yoshikazu
Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College
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Marugami Yoshihisa
Department Of Pathology Fujita Health University School Of Medicine
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Yasuda Mitsuhiro
Department Of General Surgery Fukuoka Dental College Hospital
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Kaneko Akihiro
Department Of Ophthalmology National Cancer Center
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Mori Yusuke
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Tsukinoki K
Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College
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Osamura R.yoshiyuki
Dept Of Pathology Tokai Univ School Of Medicine
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Watanabe Yoshihisa
Department Of Community Health Tokai University School Of Medicine
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Tsukinoki Keiichi
Department Of Oral Pathology Kanagawa Dental College
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Yasuda Masanori
東海大学 医学部病理学
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Yasuda Masanori
Department Of Pathology Saitama Medical University International Medical Center
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Yasuda Masanori
Department Of Neurosurgery Nippon Medical School
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Watanabe Yoshihisa
Department Of Basic Geriatrics Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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Tsukinoki Keiichi
Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College
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Tsukinoki Keiichi
Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School
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TSUKINOKI Keiichi
Department of Diagnostic Science Division of Pathology, Kanagawa Dental College
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