Proliferative Potentials of Intracranial Chordomas with a Reference to Extracranial Chordomas
スポンサーリンク
概要
- 論文の詳細を見る
Some intracranial chordomas are known to have frequent recurrence in their clinical course. The biological features regulating recurrence of intracranial chordomas has not been elucidated. We studied the proliferative potentials of chordomas with an immunohistochemical staining method using anti-Ki-67 antibody, MIB-1, together with an immunohistochemical examination on the expression of p53 protein. The correlation among MIB-1 staining indices, the immunoreactivities of p53 protein and clinical courses of intracranial chordomas was analyzed retrospectively, and the statistically significant correlation between MIB-1 staining index (SI) and recurrence has been clarified. The mean MIB-1 SI of recurrent tumors was 10.2%, which was higher than that of non-recurrent tumors (2.8%). The p53 immunopositivity correlated well with recurrence and high MIB-1 SI. Literature review also showed the importance of MIB-1 SI and p53 overexpression in extracranial chordomas. In conclusion, both the examination on proliferative potentials of chordomas using MIB-1 SI and the study on the immunoreactivity of p53 protein, are important for their biological and histopathological analyses and the prediction of future recurrence.
- 日本組織細胞化学会の論文
著者
-
SASAKI Tomio
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
-
Osamura R
Department Of Pathology Tokai University School Of Medicine
-
MATSUNO Akira
Department of Neurosurgery, Teikyo University Chiba Medical Center
-
Osamura R.yoshiyuki
東海大学 医学研究科病理病態学
-
KIRINO Takaaki
Department of Neurosurgery
-
Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
-
Kirino Takaaki
群馬大学 脳神経外
-
Kirino T
Department Of Neurosurgery Tokyo University
-
Kirino Takaaki
癌研究会癌研究所
-
Kirino Takaaki
Department Of Neurosurgery University Of Tokyo Hospital
-
Osamura Yoshiyuki
東海大学 医学研究科病理病態学
-
Osamura R.yoshiyuki
東海大学 医学部病理診断学
-
Osamura R
東海大学 医学研究科病理病態学
-
Osamura R.yoshiyuki
東海大学教育・研究支援センター
-
Nagashima Tadashi
Department of Neurosurgery, Teikyo University Ichihara Hospital
-
Osamura R.Yoshiyuki
Department of Pathology, Tokai University School of Medicine
-
Kirino Takaaki
Department Of Neurosurgery Tokyo University
-
Matsuno A
Department Of Neurosurgery Teikyo University Ichihara Hospital
-
Matsuno Akira
帝京大学ちば総合医療センター 脳神経外科
-
Sasaki Tomio
Department Of Neurosurgery Gumma University School Of Medicine
-
Matsuno Akira
Department Of Biological Science Faculty Of Life And Environmental Science Shimane University
-
Matsuno Akira
Department Of Neurosurgery Teikyo University Chiba Medical Center
-
Matsuno Akira
Department Of Life Science Graduate School Of Natural Science And Technology Kanazawa University
-
Nagashima Tadashi
Department Of Baioscience And Biotechnology Shinshu University
-
Aida Masato
Department Of Life Science Graduate School Of Natural Science And Technology Kanazawa University
-
Nagashima T
Teikyo Univ. School Of Medicine Ichihara Hospital
-
Osamura R.
Tokai Univ. School Of Medicine Kanagawa Jpn
-
Osamura R.yoshiyuki
Department Of Pathology & Division Of Diagnostic Pathology Tokai University School Of Medicine
-
Kirino T
Department Of Neurosurgery University Of Tokyo Hospital
-
Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine Tokyo University
-
Osamura R.yoshiyuki
Dept Of Pathology Tokai Univ School Of Medicine
-
Matsuno Akira
Department Of Neurosurger Teikyo University Chiba Medical Center
関連論文
- Cerebellar Hemangioblastoma Manifesting as Hearing Disturbance : Case Report
- Malignant Gastric Carcinoid Causing Ectopic ACTH Syndrome : Discrepancy of Plasma ACTH Levels Measured by Different Immunoradiometric Assays
- Sevoflurane Stimulates MAP Kinase Signal transduction through the Activation of PKC α and βII in Fetal Rat Cerebral Cortex Cultured Neuron
- Immunohistochemical Analysis of Neuroendocrine (NE) Differentiation in Testicular Germ Cell Tumors (GCTs) : Use of Confocal Laser Scanning Microscopy (CLSM) to Demonstrate Direct NE Differentiation from GCTs
- Skull Base Metastasis From Follicular Thyroid Carcinoma : Two Case Reports
- Screening program of prostate cancer at Tokai University Hospital : Characterization of prostate-specific antigen measurement
- Langerhans Cell Histiocytosis Limited to the Pituitary-Hypothalamic Axis
- Spinal Tanycytic Ependymoma Associated With Neurofibromatosis Type 2 : Case Report
- Cavernous Angioma of the Internal Acoustic Meatus : Case Report
- Production of Pituitary Hormone by Human Pituitary Adenoma is under Autocrine and Paracrine Regulation of Hypothalamic Hormones Secreted from Adenoma Cells(Prof. K Watanabe Memorial Article)
- Proliferative Potentials of Intracranial Chordomas with a Reference to Extracranial Chordomas
- A-24 Immunohistochemical examination on proliferative potentials of intracranial chordomas : correlation between tumor recurrence and MIB-1 staining index
- Histopathological Review of Silent Pituitary Somatotroph Adenoma
- P4-22 Functional Differentiation and Transcription Factors in Human Non-Functioning Pituitary Adenomas
- P4-21 Immunohistochemical Study of Neural Stem Cell Marker Nestin in Human Pitutary Glands and Pituitary
- Expression of Neuro D1 in Human Nontumorous Pituitaries and Pituitary Adenomas
- Silent Somatotroph Adenoma, Detected by Catalyzed Signal Ampligication and Non-radioisotopic In sity Hybridization
- Functional and Morphological Analyses of Rab Proteins and the Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) System in the Secretion of Pituitary Hormones
- P3-24 Confocal laser scanning microscopic observation on subcellular localization of Rab3B, SNAP-25, Syntaxin and their functional role in GH secretion in rat pituitary cells induced by growth hormone releasing hormone and somatostatin
- Improved ultrastructural double staining method of rat growth hormone and its mRNA using LR White resin
- Growth hormone-releasing hormone(GHRH)expression in pituitary somatotroph adenomas studied by immunohistochemistry and in situ hybridization using catalyzed signal amplification system
- Immunohistochemical Characterization of "Hyperplasia-Adenoma Sequence" in the Pituitaries of Transgenic Mice Expressing a Human Growth Hormone-Releasing Factor Gene
- Immunohistochemical Analysis of GH-Producing Adenomas : With Special Emphasis on Plurihormonality of Individual Tumor Cells by Double Staining
- Malignant transformation of atypical endometrial hyperplasia after progesterone therapy showing germ-cell tumor-like differentiation
- Methyl Green Staining and DNA Strands In Vitro : High Affinity of Methyl Green Dye to Cytosine and Guanine
- Immunohistochemical Expression of Type-1 Carbohydrate Antigens : Availability of DU-PAN-2 on Pathological and Clinical Aspects
- Ultrastructural Studies of Calcium Location during the "Catch" Contraction of Clam Smooth Adductor Muscle Cells(Cell Biology)
- Symptomatic T2 Vertebral Hemangioma in a Pregnant Woman Treated by One Stage Combination Surgery ; Posterior Stabilization and Anterior Subtotal Tumor Resection : Case Report
- Uterine body cancer mass screening at Tokai University Hospital
- Serum carbohydrate antigen elevations in endometrial adenocarcinomas : Characterization of DU-PAN-2 expression as a tumor marker
- Modification of p53 Immunoexpression Associated with Chemotherapy Regimens in Advanced and Refractory Ovarian Cancers(Prof. K Watanabe Memorial Article)
- Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9
- A Method to Reduce Saline and Heparin in Intraoperative Cerebral Angiography : A Preliminary Report
- Coexistence of Corticotroph Adenoma and Thyrotroph Hyperplasia in a Dog(Surgery)
- Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands
- Association of hepatocyte growth factor expression with salivary gland tumor differentiation
- Expression of Bone Matrix Proteins in Malignant Myoepithelioma with Extensive Osteoid Formation Occurring in The Maxilla
- Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry
- Immunohistochemical Localization of Prostaglandin F_<2α> in Reperfused Gerbil Brain
- Double Lumbosacral Lipomas of the Dorsal and Filar Types Associated With OEIS Complex : Case Report
- Renal cell carcinoma arising in a long pre-existing angiomyolipoma
- Treatment Strategy for Recurrent and Refractory Epithelial Ovarian Cancer : Efficacy of High-Dose Chemotherapy with Hematopoietic Stem Cell Transplantation
- Mechanisms for Production and Secretion of Hormones in Physiologic and Pathologic Conditions
- Immunohistochemical Expressions of Prohormone Convertase (PC) 1/3 and PC2 in Carcinoids of Various Organs
- IA-28 3D imaging of secretory granules pathway in GH3 cell line(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Two- or Three-Dimensional Imagings of Simultaneous Visualization of Rat Pituitary Hormone and Its mRNA : Comparison between Electron Microscopy and Confocal Laser Scanning Microscopy with Semiconductor Nanocrystals (Quantum dots)
- II-B-04 Observation of pituitary hormone and its mRNA using nanocrystal (Quantum dot) under confocal laser scanning microscopy(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Confocal Laser Scanning Microscopic Imaging of Subcellular Organelles, mRNA, Protein Products, and the Microvessel Environment
- B-8 Three-dimensional (3D) imaging of the hormone-secreting cells and their microvessels environments in estrogen-induced prolactinoma of the rat pituitary gland by confocal laser scanning microscopy (CLSM)
- Central neurocytoma with unusually intense FDG uptake : Case report
- CROSS TALK BETWEEN HOST CELLS AND SYMBIONTS OF THE BEARD WORM, OLIGOBRACHI MASHIKOI, POGONOPHORA : DISCUSSION FROM A CYTOARCHITECTURAL VIEWPOINT(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Soci
- VISUALIZATION OF BACTERIOCYTES IN THE TROPHOSOME OF THE BEARD WORM, OLIGOBRACHIA MASHIKOI(Taxonomy and Systematics,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- VARIATION ON MORPHOLOGY OF TENTACLES OF THE BEARD WORM, POGONOPHORA(OLIGOBRACHIA MASHIKOI)(Taxonomy and Systematics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- HISTOCHEMICAL STUDY OF THE TROPHOSOME OF THE BEARD WORM, POGONOPHORA (OLIGOBRACHIA MASHIKOI)(Taxonomy and Systematics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- MORPHOLOGICAL, PHYSIOLOGICAL AND ECOLOGICAL STUDY OF THE BEARD WORM, POGONOPHORA (OLIGOBRACHIA MASHIKOI)(Taxonomy and Systematics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- External Morphology of the Posterior End, the "Opisthosoma", of the Beard Worm Oligobrachia mashikoi (Pogonophora)
- Increased phosphorylation of Akt in triple-negative breast cancers
- Analyses of Factors Influencing the Acute Effect of Octreotide in Growth Hormone-secreting Adenomas
- A Comparative Study of Body Wall Structures of a Pogonophore and an Annelid from a Phylogenetic Viewpoint(Morphology)
- Physiological and ultrastructural studies on glycerinated body wall of sea cucumber
- IA-25 Studies on regulated secretion pathway in GH3 stable cell line expressing EYFP-GH fusion protein(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Spontaneous Intracranial Hypotension Associated With Bilateral Chronic Subdural Hematomas
- Application of Ultrastructural In Situ Hybridization Combined with Immunohistochemistry to Pathophysiological Studies of Pituitary Cell: Technical Review (Recent Progress In Gene Histochemistry)
- SII-2 Ultrastructural simultaneous identification of growth hormone and its messenger ribonucleic acid using combined immunohistochemistry and non-radioisotopic in situ hybridization method
- Olfactory Neuroblastoma Causing Ectopic ACTH Syndrome
- Application of Genetic Engineering Technologies for the Study of Pituitary Development and Neoplasms
- Myxoid Leiomyoma of the Vulva : A Case Report
- P4-51 Immunohistochemical heterogeneity of type 1 blood group antigen expressions in testicular germ cell tumors
- P4-50 Histological Investigation on Neuroendocrine Differentiation in Human Germ Cell Tumors Using Immunohistochemical Techniques
- A monoclonal antibody, mH1, specifically recognizes microvilli of dividing HeLa cells
- Cerebral Hyperperfusion Syndrome Associated With Non-convulsive Status Epilepticus Following Superficial Temporal Artery-Middle Cerebral Artery Anastomosis : Case Report
- Pharmacological Effect of Endothelin, an Endothelium-derived Vasoconstrictive Peptide, on Canine Basilar Arteries
- Suprasellar Ectopic Pituitary Adenoma : Case Report
- Generation and characterization of a monoclonal antibody, mH1, raised against mitotic HeLa cells
- Clipping of Vertebro-basilar Aneurysms by the Transoral Transclival Approach
- Expression of Transcriptional Factors of GATA4, GATA6 and SF-1 in the Developmental Process of Rat Adrenal Cortex; the Possible Contribution of GATA4 in Limited Expression before Zonal Establishment
- Localization and Alteration of Immunoreactive Endothelin-1 in Canine Basilar Arteries Following Subarachnoid Hemorrhage
- Effect of Edaravone on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage
- Effect of High-dose Methylprednisolone on Vasospasm After Subarachnoid Hemorrhage
- Basic and Translational Research on Proteinase-Activated Receptors: The Role of Thrombin Receptor in Cerebral Vasospasm in Subarachnoid Hemorrhage
- Surgical Treatment of Non-ruptured Giant Occipital Arteriovenous Malformations With Frequent Migraine-Like Headache : Two Case Reports
- Glutathione-Peroxidase (GSH-PO) and Androgen Action in Prostate : An Immunohistochemical Study
- Effect of Intracisternal Injection of Endothelin-1 on Regional Cerebral Blood Flow in Cats
- Nestin Expression in Vascular Malformations : A Novel Marker for Proliferative Endothelium
- Changes in Glutathione Peroxidase and Lipid Peroxides in Cerebrospinal Fluid and Serum after Subarachnoid Hemorrhage : With Special Reference to the Occurrence of Cerebral Vasospasm
- In Vitro Evaluation of the Inhibitory Action of PGI_2 to Vasoconstrictions Induced by Various Prostaglandins,Serotonin and Hemoglobin Using the Canine Basilar Artery
- Informed Consent in Relation to Management of Acoustic Neurinoma : Clinical Analysis of 7-Year Results in 214 Consecutive Cases
- Clinical Usefulness of DU-PAN-2 in Endometrial Adenocarcinomas(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Immunohistochemical Studies on Expressions of DU-PAN-2, CA19-9, Le^a, and Le^b in Thyroid Tumors
- Evaluation of tinnitus before and after microsurgical resection of acoustic tumors
- Anterior Transpetrosal Approach for Pontine Cavernous Angioma
- Therapeutic strategy targeting the mTOR-HIF-1α-VEGF pathway in ovarian clear cell adenocarcinoma
- 31-III-03 In vitro and in vivo growth suppression of rat C6 glioma cells using antisense oligonucleotide for microtubule-associated protein 1A messenger ribonucleic acid(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY A
- CISTERNAL TALC INJECTION IN DOG CAN INDUCE DELAYED AND PROLONGED ARTERIAL CONSTRICTION RESEMBLING CEREBRAL VASOSPASM MORPHOLOGICALLY AND PHARMACOLOGICALLY
- P-23-B New Hypothesis of the Antigen Retrieval Mechanism by High-Temperature Heating in Irnmunohistochemistry of Ki-67 and Proliferating Cell Nuclear Antigen(PCNA)(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYT
- Apoptotic Cells in the Human Endometrium and Placental Villi : Pitfalls in Applying the TUNEL Method
- Functional molecular morphology of anterior pituitary cells, from hormone production to intracellular transport and secretion
- Worldwide Academic Contributions of Japanese Neurosurgeons : Annual Meeting : President's Keynote Lecture
- Nonconvulsive Status Epilepticus During Perioperative Period of Cerebrovascular Surgery
- Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency