Nestin Expression in Vascular Malformations : A Novel Marker for Proliferative Endothelium
スポンサーリンク
概要
- 論文の詳細を見る
Cavernous angiomas (CAs) and arteriovenous malformations (AVMs) sometimes show growth or de novo appearance. Proliferative capacity of the endothelium is evident in such malformations. Intermediate filament nestin is a newly identified marker for proliferative endothelium, which was originally detected in the neuroepithelial stem cells of the embryonal central nervous system. Immunohistochemical analysis of nestin was evaluated as a marker for proliferative capacity of endothelial cells by comparison with proliferating cell nuclear antigen (PCNA). Sixteen of 27 CAs and 13 of 20 AVMs were positive for nestin. Likewise, 12 of 27 CAs and 10 of 20 AVMs were positive for PCNA. Nestin staining was stronger in the typical malformative vessels of CAs than in AVMs, in both the endothelial cells and the interstitial cells. Newly formed endothelial cells expressed nestin strongly in the reactive tissues including organizing or encapsulated hematomas. These results suggest that neovascularization occurs in the process of repeated bleeding and remodeling of hematomas.
- 日本脳神経外科学会の論文
- 2006-03-15
著者
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SASAKI Tomio
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
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SAITO Nobuhito
Department of Neurosurgery, The University of Tokyo Hospital
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HOYA Katsumi
Department of Neurosurgery, Teikyo University Chiba Medical Center
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Shimizu Tatsuya
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Sasaki Tomio
Department Of Neurosurgery Neurological Institute Graduate School Of Medical Sciences Kyushu Univers
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Saito Nobuhito
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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Saito Nobuhito
Department Of Neurosurgery Gunma University Graduate School Of Medicine
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IMAI Hideaki
Departments of Neurosurgery Gunma University school of Medicine
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TAKEUCHI Toshiyuki
Department for Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University
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Imai Hideaki
Department Of Neurosurgery Gunma University Graduate School Of Medicine
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Imai Hideaki
Department Of Electronic And Information Engineering Faculty Of Engineering Hokkaido University
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Sugawara Ken-ichi
Department Of Neurosurgery Gunma University Graduate School Of Medicine
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Hoya Katsumi
Department Of Neurosurgery Koshigaya Hospital Dokkyo University School Of Medicine
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Hoya Katsumi
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo Tokyo
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Shimizu Tatsuya
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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TOSAKA Masahiko
Department of Neurosurgery, Gunma University Graduate School of Medicine
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Takeuchi Toshiyuki
Department For Molecular Medicine Institute For Molecular And Cellular Regulation Gunma University
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Tosaka Masahiko
Department Of Neurosurgery Fujioka General Hospital
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Tosaka Masahiko
Department Of Neurosurgery Gunma University Graduate School Of Medicine
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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Shimizu Tatsuya
Department Of Neurosurgery Gunma University Graduate School Of Medicine
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Shimizu Tatsuya
Department Of Cardiology Jr Tokyo General Hospital
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Shimizu Tatsuya
Department Of Biochemistry And Molecular Biology Nippon Medical School
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Hoya Katsumi
Department Of Neurosurgery Dokkyo Medical University Koshigaya Hospital
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Imai Hideaki
Department of Applied Chemistry, Faculty of Engineering, Nagoya University
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