Changes in Glutathione Peroxidase and Lipid Peroxides in Cerebrospinal Fluid and Serum after Subarachnoid Hemorrhage : With Special Reference to the Occurrence of Cerebral Vasospasm
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the pathogenesis of delayed cerebral vasospasm after subarachnoid hemorrhage (SAH), the authors studied changes in lipid peroxides (measured as thiobarbituric acid reactive substances, TRS) and their scavenging enzyme, glutathione peroxidase (GPx), in the cerebrospinal fluid (CSF) and the serum of SAH patients and normal subjects. The CSF of the normal subjects was almost devoid of both TRS and GPx. A sudden increase in GPx activity in the CSF of SAH patients appeared to be due to the efflux of serum GPx to the subarachnoid space. GPx in the CSF decreased within 2-4 days after SAH, and in some cases the TRS content then became elevated and delayed vasospasm ensued. Following SAH, serum TRS increased, reaching a plateau 4-5 days after onset. GPx also increased 1 or 2 days later. The increase in serum TRS appeared to be a consequence of blood clotting within the subarachnoid space and may have stimulated GPx activity. The findings suggest that lipid peroxides present in the CSF and the serum of SAH patients may be responsible for development of delayed vasospasm and that serum GPx might play an important role in controlling it.
- 日本脳神経外科学会の論文
- 1988-07-15
著者
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SASAKI Tomio
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
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Watanabe Takashi
Department of Chemistry, Graduate School of Science, Kyoto University
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YOSHIMURA Shinichi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Sano Keiji
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo; Department Of Neurosurgery Tokyo
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TAKAKURA Kintomo
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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Takakura Kintomo
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Asano Takao
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Asano Takao
Department Of Applied Chemistry Seikei University
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FUCHINOUE Tokurou
Department of Neurosurgery, Toshima Tokyo Municipal Hospital
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ABE Kouichi
Eisai Research Laboratories
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Sano Keiji
Department Of Hepato-biliary-pancreatic Surgery Japanese Red Cross Medical Center
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Fuchinoue Tokurou
Department Of Neurosurgery Toshima Tokyo Municipal Hospital
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Yoshimura Shinichi
Department Of Molecular Life Science Tokai University School Of Medicine
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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Takakura Kintomo
Department Of Neurosuegery National Cancer Center Hospotal
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Watanabe Keiichi
Department Of Pathology School Of Medicine Tokai University
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Yoshimura Shinichi
Department Of Molecular Life Science (cell Biology) Tokai University School Of Medicine
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Yoshimura Shinichi
Department Of Pathology School Of Medicine Tokai University
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Sano Keiji
Department Neurosurgery University Of Tokyo
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Watanabe Keiichi
Department Of Applied Biological Sciences Saga University
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Sano Keiji
Deparmtent Of Neurosurgery:faculty Of Medicine University Of Tokyo
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Watanabe Takashi
Department Of Applied Physics Tohoku University
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Watanabe Takashi
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Yoshimura Shinichi
Department of Molecular Life science (Cell Biology Division), Tokai University School of Medicine
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WATANABE Keiichi
Department of Pathology, School of Medicine, Tokai University
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