Effect of High-dose Methylprednisolone on Vasospasm After Subarachnoid Hemorrhage
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概要
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The effects of high-dose methylprednisolone (MP) on vasospasm following subarachnoid hemorrhage (SAH) were investigated. In a double hemorrhage canine model, administration of high-dose MP (10 mg/kg, every 12 hours) reduced angiographic narrowing of the basilar artery and prevented morphological changes in the arterial wall. In addition, increased platelet aggregation observed from days 4 to 7 in untreated SAH dogs was inhibited by the MP treatment. An in vitro experiment showed that MP inhibited platelet aggregation dose-dependently. High-dose MP had a nonspecific vasodilatory effect on the smooth muscle of the basilar artery. In another SAH model with dysautoregulation of cerebral blood flow (CBF), intravenous MP administration markedly attenuated the decrease in both blood pressure and CBF caused by exsanguination. These results indicate that MP has beneficial effects in normalizing CBF dysautoregulation following SAH. High-dose MP has several advantages for preventing and improving the multiple pathological status in cerebral vasospasm following SAH.
- 日本脳神経外科学会の論文
- 1991-01-15
著者
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SASAKI Tomio
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
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Sasaki Tomio
Department Of Neurosurgery Neurological Institute Kyushu University Graduate School Of Medical Scien
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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TAKAKURA Kintomo
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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NAKAGOMI Tadayoshi
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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SAITO Isamu
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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Takakura Kintomo
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Nakagomi Tadayoshi
Department Of Neurosurgery Teikyo University School Of Medicine
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Saito Isamu
Department Of Neurosurgery Kyorin University School Of Medicine
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YAMAKAWA Kenta
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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Yamakawa Kenta
Yamakawa Neurological Clinic
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TSUBAKI Shinichi
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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Tsubaki Shinichi
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Saito Isamu
Department Neurosurgery University Of Tokyo
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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Takakura Kintomo
Department Of Neurosuegery National Cancer Center Hospotal
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NAKAGOMI Tadayoshi
Department of Neurosurgery, Teikyo University School of Medicine
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