Measurement of Serum Alkaline Phosphatase Isozyme I in Brain-damaged Patients
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概要
- 論文の詳細を見る
The authors measured alkaline phosphatase isozyme I (ALP-I) in sera of 24 brain-damaged patients and four with disorders other than brain damage. The study population comprised three patients with postresuscitation encephalopathy, four with ruptured cerebral aneurysms, 14 with acute subdural hematoma and cerebral contusion, and three with nontraumatic intracerebral hemorrhage. ALP-I detected in brain damage is physicochemically different from the other known ALP-Is that appear in patients with obstructive jaundice or hepatoma. In the brain-damaged patients, ALP-I became elevated about 7 days after admission and markedly increased as secondary brain damage developed. Excluding patients who died within 9 days of admission, the maximum serum ALP-I concentration was well correlated with the functional outcome. In cases in which barbiturate therapy was effective, the appearance of ALP-I was delayed and its elevation was suppressed. The results of this study suggest that measurement of serum ALP-I is useful not only in the management but also in predicting the prognosis of brain damage.
- 日本脳神経外科学会の論文
- 1989-11-15
著者
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TAKAKURA Kintomo
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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Mii Koji
Department of Neurosurgery,University of Tokyo
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Takakura Kintomo
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Mii Koji
Department Of Emergency Medicine Faculty Of Medicine University Of Tokyo
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Ohkubo Akiyuki
Department of Laboratory Medicine, University of Tokyo
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Tsuzuki Masakazu
Department Of Mechanical Engineering Kansai University
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Tsuzuki Masakazu
Department Of Emergency Medicine Faculty Of Medicine University Of Tokyo
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Yamashita Masatomo
Department Of Emergency Medicine Institute Of Clinical Medicine University Of Tsukuba
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Sasaki Masaru
Department Of Emergency Medicine Faculty Of Medicine University Of Tokyo
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Sasaki Masaru
Department Of Neurosurgery Showa General Hospital
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Ohkubo Akiyuki
Department Of Clinical Laboratory Medicine Faculty Of Medicine University Of Tokyo
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Sasaki Masaru
Research And Development Department Koito Manufacturing Co. Ltd.
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YOSHINOYA Sadayoshi
Department of Clinical Laboratory Medicine, Faculty of Medicine, University of Tokyo
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Yoshinoya Sadayoshi
Department Of Clinical Laboratory Medicine Faculty Of Medicine University Of Tokyo
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Takakura Kintomo
Department Of Neurosuegery National Cancer Center Hospotal
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Sasaki Masaru
Department Of Electrical Communications Faculty Of Engineering Tohoku University
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MII Koji
Department of Emergency Medicine, Faculty of Medicine, University of Tokyo
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