The Role of humoral Agents Released by Platelet Aggregation in the Pathogenesis of Transient Ishchemic Attacks

スポンサーリンク

概要

• 論文の詳細を見る

• For the purpose of investigating the role of the humoral agents released by platelet aggregation in the pathogenesis of transient cerebral ischemic attacks (TIA), the products of platelet suspension which was aggregated by Thrombin was infused as a bolus into the internal carotid artery in rabbits. Before injection, formed elements were filtered off by the use of a milipore filter. The injected material was supposed to contain substances released by platelet aggregation, such as serotonin, histamin, ADP and so on as well as various prostaglandins, among which the existence of thromboxane A2(TXA_2)possessing a potent vasoconstricting effect was known.Before and after the injection, the cortical CBF(coCBF), EEG and systemic arterial pressure (SAP) were continuously monitored under controlled respiration. According to the pattern of response of coCBF following injection of Thrombin-added PRP (T-PRP), a total of 29 rabbits were divided into three groups. In the first group(7/29), the coCBF decreased markedly immediately after the injection, which was accompanied by supression of EEG. Such an ischemic change lasted for 5-10 minutes and then gradually subsided. In two additional rabbits which exhibited the same ischemic pattern, India ink was intravenously administered when the fall of coCBF was at its maximum. This revealed considerable non-filling of the capillary networks of the cerebral cortex in the injected side.The responsible agent for this remarkable cerebral ischemia was considered to be TXA_2.In the second group(9/29), a biphasic pattern (initial brief ischemia followed by more prolonged hyperemia) was observed. In the third group(13/29), transient but prominent hyperemia was observed. In the two latter groups, there were only slight supressions of EEG as compared to the first group. India ink perfusion of the brain, carried out in the two additional rabbits exhibiting this hyperemic pattern, revealed a patent cerebral microcirculation. This transient hyperemia seen in the second and the third groups was considered to be due to the action of some unknown substance which had a potent vasodilating effect. Recently found Prostacyclin (PGI.)was suggested as a possible agent which caused the hyperemic response. The result of the present study is considered to indicate that the dual control system of platelet aggregation and vascular tonus by TXA_2 and Prostacyclin as proposed by Moncada et al.^<14)>is also effective to the cerebral vessels.

• 日本脳神経外科学会の論文

著者

• Mii Koji

  Department Of Emergency Medicine Faculty Of Medicine University Of Tokyo

• Asano Takao

  Department Of Applied Chemistry Seikei University

• Sano Keiji

  Department Of Hepato-biliary-pancreatic Surgery Japanese Red Cross Medical Center

• Tamura Akira

  Department Of Biochemistry Kyoto Pharmaceutical University

• Tamura Akira

  Department Of Neurosugery University Of Tokyo Hospital Tokyo Japan

• Asano Takao

  Department Of Neurosugery University Of Tokyo Hospital Tokyo Japan

• Sano Keiji

  Department Neurosurgery University Of Tokyo

• Sano Keiji

  Department Of Neurosugery University Of Tokyo Hospital Tokyo Japan

• Sano Keiji

  Deparmtent Of Neurosurgery:faculty Of Medicine University Of Tokyo

関連論文

• Use of an opened umbilical vein patch for the reconstruction of the injured biliary tract
• Diagnostic Value of Stationary potential Measurement in Head Injuries
• B-51. Engineering Aspects of Skull Fracture and Brain Damage
• B-13. Ultrastructure and Ultracytochemistry of the Experimental Epileptic Focus
• Fine Structure of Human Epileptogenic Foci : Preliminary report
• A-26. Sequelae of the Cerebral Contusion : Incidence of the Posttraumatic Epilepsy
• Statistical Analysis of Chronic Subdural Hematoma in 309 adult Cases
• Mechanism and Dynamics of Closed Head Injuries (Preliminary Report)
• OJ-179 Long Term Effect of Granulocyte Colony-Stimulating Factor as a Novel and Noninvasive Regeneration Therapy Against Atherosclerotic Peripheral Artery Disease(Peripheral Circulation/Vascular Disease 1 (H) : OJ21)(Oral Presentation (Japanese))
• Experimental Head Injury & Concussion in Monkey Using Pure Linear Acceleration Impact
• l-1. Mechanism and dynamics of closed head injuries
• A 5-Year Survivor with 2 Previous Surgical Resections of Extrahepatic Metastases for Hepatocellular Carcinoma after Extended Right Hepatectomy
• Assessment of hepatic reserve for indication of hepatic resection : decision tree incorporating indocyanine green test
• Anatomical Segmentectomy of the Pancreas Head : Can this Procedure be Curatively Applied for Intraductal Papillary Mucinous Tumors?
• Cerebral Acetylcholine Levels and Long-Term Spatial Cognitive Impairment Following Middle Cerebral Artery Occlusion in Rats
• B-81. Arterio-Venous Nalformation in Children
• B-54. Experiment on angiotactic Surgery for Cerebro-Vascular Diseases
• S-5. The Motor Responses to the Stimulation of the Rostral Human Brain Stem (Symposium:Human Depth Electrophysiology)
• 17 17. Upon Stimulation of Human Hypothalamus (PROCEEDINGS OF THE IVth ANNUAL MEETING OF THE JAPAN SOCIETY FOR RESEARCH IN STEREOENCEPHALOTOMY)
• Laser Surgery of Basal, Orbital and Ventricular Meningiomas which are Difficult to Extirpate by Conventional Methods
• EFFECT OF INTRACELLULAR AND EXTRACELLULAR pH ON SHAPE CHANGE OF HUMAN ERYTHROCYTES INDUCED BY AMPHIPHILIC DRUGS
• Short-latency Somatosensory Evoked Potentials in Patients with Brain Stem Tumor : Study of N_lt20gt and N_lt18gt Potentials
• Ultrastructural and MRI study of the substantia nigra evolving exofocal post-ischemic neuronal death in the rat
• Demonstration of Antigenic and Genotypic Variation in Orientia tsutsugamushi Which Were Isolated in Japan, and Their Classification into Type and Subtype
• ANALYSIS OF CONSTITUTIONAL PROTEINS AND ANTIGENIC COMPONENTS IN RICKETTSIA TSUTSUGAMUSHI
• Experimental Head Injury with Lateral Impact Using Monkeys (Preliminary Report) : Dynamic and Pathological Investigation
• Phylogenetic Characterization of Orientia tsutsugamushi Isolated in Taiwan According to the Sequence Homologies of 56-kDa Type-Specific Antigen Genes
• Epidemiological Survey of Orientia tsutsugamushi Distribution in Field Rodents in Saitama Prefecture, Japan, and Discovery of a New Type
• Isolation of Orientia tsutsugamushi from Leptotrombidium fuji and Its Characterization
• Decreased Prevalence of Orientia tsutsugamushi in Trombiculid Mites and Wild Rodents in the Primorye Region, Far East Russia
• 20. Stationary Potential Changes in Epilepsy
• Laparoscopic hepatectomy for hepatocellular carcinoma in cirrhotic patients
• Relief of Intractable Pain from Neurosurgical Point of View with Reference to Present Limits and Clinical Indications : A Review of 100 Consecutive Cases
• S-9. Posteromedical Hypothalamotomoy for Intractable Pain : Basic and Clinical Studies
• S-4. Sensory Neurons of the Hypothalamus and Thalamus
• S-6. Single Unit Analysis on Reticular Neurons of the Midbrain Tegmentum Near the Central Gray
• Complete remission of disease for 5 years following initial and repeat resection of the liver for the removal of 22 metastases of colorectal origin
• Clipping of Vertebro-basilar Aneurysms by the Transoral Transclival Approach
• 4. New Diagnostic Method of Brain Tumors by Cell Culture of the Cerebrospinal Fluid : Millipore Filter-Cell Culture Method
• New Diagnostic Method of Brain Tumors by Cell Culture of the Cerebrospinal Fluid : Millopor Filter-Cell Culture Method
• Experimental and Clinical Studies of Radiosensitizers in Brain Tumors, with Special Reference to BUdR-Antimetabolite Continuous Regional Infusion-Radiation Therapy (BAR therapy)
• A CASE OF CLINICALLY DIAGNOSED PURE SEPTAL INFARCTION
• -0431-EVALUATION OF VIABLE MYOCARDIUM BY EXERCISE 201-Tl MYOCARDIAL SCINTIGRAPHY USING THE REINJECTION METHOD
• Changes in Glutathione Peroxidase and Lipid Peroxides in Cerebrospinal Fluid and Serum after Subarachnoid Hemorrhage : With Special Reference to the Occurrence of Cerebral Vasospasm
• In Vitro Evaluation of the Inhibitory Action of PGI_2 to Vasoconstrictions Induced by Various Prostaglandins,Serotonin and Hemoglobin Using the Canine Basilar Artery
• Intracranial and Cerebral Perfusion Pressures in Relation to Auditory Brainstem Responses and Initiation of Secondary Brainstem Damage
• Clinical Application of the Multidimensional Neurological Monitoring System and the Cerebrosystemic Hemodynamic Profile for Critically Ill Neurosurgical Patients
• A-35. The Electrophysiological Properties of Brain Tumor Cells and Application to Diagnosis
• A-77. Transsphenoidal Approach for the Treatment of Pituitary Tumors-Its Limitation
• A-68. The Ultrastructure of Two-Cell Pattern Pinealomas
• 29. Enhancement Tumor Immunity-Modification of Autochthonous Antigen with Mercaptounadecahydroduodecaborate
• 45. Relative Shunt Flow in Cerebral Arteriovenous Malformations
• 1. Pulseless Disease : Summary of Our 62 Cases
• A-69. Cell Kinetic Changes of Malignant Glioma Cells Treated with DBcAMP
• B-9. The Effect of (But)_2cAMP on the Malignant Glioma Calls : from the View Point of Cell Kinetics
• Ventricular Hemorrhage at an Early Stage of Moyamoya Disease : Case Report
• Development of an Optimum Dosage Regimen for Pentobarbital in Patients with Severe Head Injury
• Differential Effects of Activity and Climate on Onset of Subarachnoid Hemorrhage
• S-H-3 S-H-3. Surgical Treatment of Cerebral Aneurysms and Arterio-venous Malformations : With Special Reference to Artificial Embolization (Symposium H: Intracranial Aneurysm and Arterio-venous Malformation)
• Reversibility of Cerebral Function Assessed by Somatosensory Evoked Potentials and its Relation to Intracranial Pressure : Report of Six Cases with Severe Head Injury
• Measurement of Serum Alkaline Phosphatase Isozyme I in Brain-damaged Patients
• Single HCC between 2 and 5cm : the grey zone : Surgeon's perspective
• Cerebrospinal Fluid Cytokines in Salmonella Urbana Encephalopathy
• Graphical Degree Sequence Problems
• Removal of Endocrine Disruptors by Selective Sorption Method using Activated Carbons (ノーベル化学賞記念特集号/TMS特集号(3))
• Phonon Effect on the Superconducting Transition Temperature of a Small Particle
• Cementless total hip arthroplasty using porous-coated Biomet acetabular cups (Hexloc and Ringloc types)
• Delayed Traumatic Intracerebellar Hematoma:Correlation Between the Location of the Hematoma and the Pre-existing Cerebellar Contusion : Case Report
• A-102. Experimental Study on Vasospasm of the Brain
• The Effect of Indomethacin on Ischemic Brain Edema : A Study Using Cat Middle Cerebral Artery Occlusion Combined with Recirculation
• S-III-8. Surgical Treatment of Intracranial Aneurysms in the Acute Stage
• Partitioning a Polygonal Region into Trapezoids
• The Role of humoral Agents Released by Platelet Aggregation in the Pathogenesis of Transient Ishchemic Attacks
• 26 Prognosis and Long-term Results of Surgital Treatment of the Pulseless Disease
• B-3. Immunological Diagnosis of Brain Tumor
• B-6. Enhancement of Anti-tumor Immunity-Clinical Experience of Autochthonous Tumor Homogenate Treared with Sodium Di-undecahydrododecaboranyl sulfide (oxidized form of mercaptoundecahydrododecaobrate)
• 57 Neurogenic Bleeding and Ulceration in the Upper Alimentary Tract
• S-9. Clinical Aspects of Cervical Cord Tumors
• Dynamic Orthogonal Segment Intersection Search and Its Applications(GRAPH THEORY AND APPLICATIONS)
• Hypertensive Cerebellar Hemorrhage and Cerebellar Hemorrhage Caused by Cryptic Angioma : Analysis of Clinical Observations, CT Findings and Outcome
• D-16. On the 'Cerebral Juxta-basal Telangiectasia' (Special Discussion:Occulsive Arterial Disorders of the Main Trnks of the Cerebral Arteries,Particularly Found in Japan)
• Imunological Studies of Pulseless Discase
• A-17. An Experimental Study on the Rupture of Aneurysm
• Cerebroprotective Effects of a Novel Pyrazoline Derivative,MS-153,on Focal Ischemia in Rats
• Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma
• Computerized Stationary Potential Encephalography in Patients with Intracranial Organic Lesions
• Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy : multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery
• An Approximation Algorithm for MAX 3SAT
• A-41. A Study on CSF Pulsation
• Analysis of Scanning Tunneling Microscopy Images and Scanning Tunneling Spectrum of Electrons Confined in Equilateral Triangular Quantum Corrals(Condensed matter: structure and mechanical and thermal properties)
• 76. A simple stereotaxic apparatus.
• 96. Gustatory Perspiration and Gustolacrimal Reflex.
• S-D-3 S-D-3. Basilar Impression (Symposium D: Congenital Anomalies)
• An Approach to the Subgraph Homeomorphism Problem(GRAPH THEORY AND APPLICATIONS)
• Morphometric and immunohistochemical study of cholangiolocellular carcinoma : comparison with non-neoplastic cholangiole, interlobular duct and septal duct
• Portal vein resection in pancreaticoduodenectomy (with video)
• S-5. Single Unit Analysis on Reticular Neurons of Midbrain Tegmentum near the Central Gray : The Second Report:In Relation to Hypothalamus
• Whereabouts of an internal short stent placed across the pancreaticojejunostomy following pancreatoduodenectomy
• 12. Hemangioblastomas of the Brain
• 45. Relative Shunt Flow in Cerebral Arteriovenous Malformations

もっと見る 閉じる

スポンサーリンク