In Vitro Evaluation of the Inhibitory Action of PGI_2 to Vasoconstrictions Induced by Various Prostaglandins,Serotonin and Hemoglobin Using the Canine Basilar Artery

概要

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Current investigations have indicated that prolonged vasoconstriction in vasospasm following subarachnoid hemorrhage due to rupture of intracranial aneurysms is the result of a combined action of various vasoconstrictive agents such as serotonin, oxyhemoglobin, thrombin and prostaglandins. PGI_2 (prostacyclin), on the other hand, has been known to possess antagonistic actions to some of the above agents. To elucidate the role of PGI_2 as a natural protecting factor against the occurrence of vasospasm, its inhibitory action against vasoconstrictions induced by serotonin, oxyhemoglobin, PGA_2, PGD_2, PGE_2 and PGF_<2α>was studied in vitro using the canine basilar artery. PGI_2in concentration of 10^<-6>M caused vasodilation ranging between 20 to 70% of the basal contraction developed by each agonist. Thus it was revealed that PGI_2 caused a significant dilation of the artery which had been constricted by any of the above agents. Since the progressive diminution in PGI_2 synthesis in experimental SAH has been previously demonstrated, the result of the present study indicates a possible benefit of the use of PGI_2 as well as the need for preservation of PGI_2 synthesis in any pharmacological treatment of vasospasm.
日本脳神経外科学会の論文
1982-07-15