Effect of Intracisternal Injection of Endothelin-1 on Regional Cerebral Blood Flow in Cats
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概要
- 論文の詳細を見る
The effect of endothelin-1 on regional cerebral blood flow (rCBF) was investigated in adult mongrel cats. Endothelin-1 was injected into the cisterna magna and rCBF was measured by the hydrogen clearance method before and every 30 minutes for 180 minutes after the injection. Endothelin-1 (10^<-11> mol and 10^<-9> mol) induced a significant decrease in rCBF and an increase in arterial pressure. The effects of endothelin-1 on rCBF and arterial pressure were mediated, at least in part, by Ca^<2+>, because pretreatment with intracisternally injected nicardipine prevented the changes. Cerebral angiograms obtained before and after endothelin-1 injection demonstrated severe constriction of the basilar artery, but constriction of the internal carotid and middle cerebral arteries was mild. Since the rCBF measured was in the territory of the middle cerebral artery, the decrease in blood flow was probably not solely due to the artery constriction. Other mechanisms such as arteriole constriction and/or regulation of rCBF by the central nervous system may also occur.
- 日本脳神経外科学会の論文
- 1991-10-15
著者
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SASAKI Tomio
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
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Sasaki Tomio
Department Of Neurosurgery Neurological Institute Kyushu University Graduate School Of Medical Scien
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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TAKAKURA Kintomo
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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SAITO Isamu
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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Takakura Kintomo
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Saito Isamu
Department Of Neurosurgery Kyorin University School Of Medicine
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MORIMOTO Tadashi
Department of Neurosurgery, Saitama Medical Center
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HANAMURA Tetsu
Department of Neurosurgery, Tokyo Metropolitan Police Hospital
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Hanamura Tetsu
Department Of Neurosurgery Tokyo Metropolitan Police Hospital
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Morimoto Tadashi
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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Saito Isamu
Department Neurosurgery University Of Tokyo
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Sasaki Tomio
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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Takakura Kintomo
Department Of Neurosuegery National Cancer Center Hospotal
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