Safety and Efficacy of Fasudil Monotherapy and Fasudil-Ozagrel Combination Therapy in Patients With Subarachnoid Hemorrhage : Sub-analysis of the Post-marketing Surveillance Study
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概要
- 論文の詳細を見る
Sub-analysis of the fasudil post-marketing surveillance study compared the safety and efficacy of fasudil plus ozagrel to fasudil only. A total of 3690 patients received fasudil and 1138 received fasudil plus ozagrel between 1995 and 2000. The occurrence of adverse events, occurrence of low density areas associated with vasospasm on computed tomography, absence of symptomatic vasospasm, and poor clinical outcomes associated with vasospasm were compared between the fasudil and fasudil plus ozagrel groups. The pharmacokinetics of fasudil were assessed in 5 patients with subarachnoid hemorrhage. The drug interaction between fasudil and ozagrel was pharmacologically investigated in vitro and in vivo. The occurrence of adverse events and clinical outcomes were similar between the two groups. The occurrences of symptomatic vasospasm and low density areas were lower in the fasudil group than in the fasudil plus ozagrel group. The average trough value (8-hour value) of the fasudil active metabolite, hydroxyfasudil, was 50 nM. Fasudil showed no pharmacological interaction with ozagrel. The combination of fasudil plus ozagrel was well tolerated, but did not result in better efficacy than fasudil only.
- 社団法人 日本脳神経外科学会の論文
- 2008-06-15
著者
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TAKAKURA Kintomo
Department of Neurosurgery, Faculty of Medicine, University of Tokyo
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SUZUKI Yoshio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Shibuya Masato
Department Of Neurosurgery Chukyo Hospital
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Shibuya Masato
Department Of Media And Image Technology Faculty Of Engineering Tokyo Polytechnic University
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Satoh S
Scientific Affairs & Sales Promotion Department Asahi Kasei Pharma Corporation
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Satoh Shin-ichi
Scientific Affairs & Sales Promotion Department Asahi Kasei Pharma Corporation
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Takakura Kintomo
Department Of Neurosurgery Tokyo Women's Medical University Hospital
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Seto Minoru
Research Center Asahi Kasei Pharma Corporation
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SUGIYAMA Hirotoshi
Reliability Assurance Department, Asahi Kasei Pharma Corporation
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Sugiyama Hirotoshi
Reliability Assurance Department Asahi Kasei Pharma Corporation
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Takakura Kintomo
Department Of Neurosuegery National Cancer Center Hospotal
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Shibuya Masato
Department Of Forest Science Faculty Of Agriculture Hokkaido University
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Suzuki Yoshio
Department Of Electronics Fukuoka Institute Of Technology
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Suzuki Yoshio
Department Of Neurosurgery Nagoya Daini Red Cross Hospital
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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