Z-335,a Thromboxane A_2 Receptor Antagonist, Suppresses the Progression of Arachidonic Acid-Induced Hind Limb Gangrene in Rats
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概要
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We have developed a new rat model of gangrenous peripheral vascular disease with vascular injury and occlusive thrombi. Rat hind limb gangrene was induced by injecting arachidonic acid (2 mg/leg) into the femoral artery. Using this model, we evaluated the effect of a thromboxane A_2 receptor antagonist, Z-335,on the progression of hind limb gangrene. Z-335 (10 mg/kg/d, p.o.) ameliorated arachidonic acid-induced hind limb gangrene. In contrast, daltroban (10 mg/kg/d, p.o.) and cilostazol (100 mg/kg/d, p.o.) tended to improve the hind limb gangrene but their effects failed to reach statistical significance. Z-335 (10 mg/kg. p.o.) inhibited U-46619-induced, but not collagen-induced, platelet aggregation in rat whole blood. Daltroban (10 mg/kg, p.o.) showed a tendency to inhibit U-46619-induced platelet aggregation. Cilostazol (100 mg/kg, p.o.) did not inhibit U-46619- or collageninduced platelet aggregation. Histopathological examination of the injured paws showed that Z-355 (10 mg/kg, p.o.) had partly inhibited the formation of occlusive thrombi. These results indicate that the thromboxane A_2 receptor antagonist Z-335 is effective arachidonic acid-induced hind limb gangrene in rats. Our experiments sugggest that Z-335 may be beneficial in the prevention of gangrenous peripheral vascular disease.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
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Suzuki Y
School Of Pharmaceutical Sciences University Of Shizuoka
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Takei Mineo
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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Suzuki Y
Fukuoka Inst. Technol. Fukuoka
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Takei M
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Takei Mineo
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Suzuki Y
Meijo Univ. Nagoya Jpn
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SUZUKI Yoshio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Suzuki Y
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Suzuki Y
Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph
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KURIMOTO Tadashi
Central Rsearch Laboratories, Zeria Pharmaceutical Co., Ltd.
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ITO Shigeru
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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TAMAKI Hajime
Laboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus
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FUKUDA Youichi
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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HIGASHINO Raita
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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TANAKA Kakao
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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FUKUTA Yoshihisa
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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ITO Shigeru
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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TAMAKI Hajime
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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TANAKA Takao
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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Ito S
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Suzuki Y
Faculty Of Pharmacy Meijo University
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Tanaka Kakao
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Fukuda Y
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Tamaki Hajime
The Third Department Of Internal Medicine Tokyo Medical And Dental University
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Tamaki Hajime
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Tamaki Hajime
Chemistry And Technology Of Plant Products Laboratory Kobe University
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Higashino R
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Kurimoto T
Zeria Pharmaceutical Co. Ltd. Saitama Jpn
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Kurimoto Tadashi
Central Rsearch Laboratories Zeria Pharmaceutical Co. Ltd.
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福田 陽一
Kyoto Pharmaceutical University
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福田 陽一
小城製薬株式会社研究所
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Suzuki Yoshio
Department Of Electronics Fukuoka Institute Of Technology
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Suzuki Y
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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KURIMOTO Tadashi
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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