Effects of Gonadectomy and Sex Hormones on the Induction of Hepatic CYP4A by Clofibrate in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of sex hormones on the induction of hepatic CYP4A by clofibrate were examined in intact and gonadectomized rats of both sexes by measuring the activity of lauric acid ω-hydroxylation (LAH). Although the specific activity of LAH is the same in both sexes, only in male rats, was the activity significantly increased by administration of clofibrate. In female rats, ovariectomy or testosterone treatment resulted in an enhanced response to clofibrate, similar to that observed in male rats. In ovariectomized female rats, the effect of clofibrate was decreased by estradiol. In orchiectomized male rats, testosterone had no effect on the induction of LAH by clofibrate and estradiol suppressed induction. Changes in LAH activities co-realted well with those in CYP4A proteins and CYP4A1 mRNA. These results suggest that some factors associated with female sex hormones were involved in the suppressive regulation of CYP4A induced by clofibrate.

• 公益社団法人日本薬学会の論文
• 1996-01-15

著者

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• 佐藤 正基

  School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation

• Suzuki Y

  Meijo Univ. Nagoya Jpn

• Satoh M

  Showa Pharmaceutical Univ. Tokyo Jpn

• Sato M

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Matsuura T

  Institute For Protein Research Osaka University

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• MATSUURA Teruro

  Research Institute of Drug Safety, Setsunan University

• Hiratsuka Masahiro

  Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University

• Hiratsuka Masahiro

  Faculty Of Pharmaceutical Sciences Tohoku University

• Hiratsuka Masahiro

  Department Of Surgery Center For Adult Diseases

• Suzuki Y

  Faculty Of Pharmacy Meijo University

• MATSUURA Tomomi

  Faculty of Pharmaceutical Sciences, Tohoku University

• SATO Masuo

  Faculty of Pharmaceutical Sciences, Tohoku University

• SUZUKI Yasuo

  Faculty of Pharmaceutical Sciences, Tohoku University

• 佐藤 真友美

  Univ. Shizuoka Shizuoka Jpn

• Matsuura T

  Research Institute Of Drug Safety Setsunan University

• Hiratsuka Masahiro

  Department Of Medical Genetics Tohoku University School Of Medicine

• Hiratsuka Masahiro

  Laboratory Of Pharmacotherapy Of Life-style Related Diseases Graduate School Of Pharmaceutical Scien

• Suzuki Yasuo

  Faculty Of Pharmaceutical Science Tohoku University

• Suzuki Yasuo

  Faculty Of Engineering Takushoku University

関連論文

• Protective Effect of Prostaglandin EP_4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis
• Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
• A Unique Phosphatidylinositol Bearing a Novel Branched-Chain Fatty Acid from Rhodococcus equi Binds to Influenza Virus Hemagglutinin and Inhibits the Infection of Cells
• lnhibitory action of sulfatide a putative ligand for L-selectiv on B cell proliferation and lg prodrction
• Stereoselective Permeation of New Fluorinated Quinolone Derivatives across LLC-PK_1 Cell Monolayers
• Uptake of Doxorubicin by Cultured Kidney Epithelial Cells LLC-PK_1
• Synthesis and Evaluation of Novel Thiazolidine Derivatives as Thromboxane A_2 Receptor Antagonists
• Synthesis and Platelet Aggregation Inhibitory Activities of 3-(2-Oxopropylidene)azetidin-2-one Derivatives. II
• Synthesis and Platelet Aggregation-Inhibitory Activities of Novel 3-(2-Oxopropylidene)azetidin-2-one Derivatives. I
• 製剤中のニトロプルシドナトリウム定量法に関する検討 : 直接吸光度法,スルフィド法,高速液体クロマトグラフ法についての検討
• Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
• Thermodynamic Effects of Hopanoids on Synthetic and Bacterial Phospholipid Membranes
• Interactions between Bacteriohopane-32,33,34,35-tetrol and Liposomal Membranes Composed of Dipalmitoylphosphatidylcholine
• ATOMIC FORCE MICROSCOPY OF DIMYRISTOYLPHOSPHATIDYLCHOLINE MEMBRANES
• The New Role of Disodium Cromoglycate in the Treatment of Adults with Bronchial Asthma
• In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)(Microbiology)
• Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells(Microbiology)
• Suppression of the Biosynthesis of Cellular Sphingolipids Results in the Inhibition of the Maturation of Influenza Virus Particles in MDCK Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
• In Vitro and in Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection(Pharmacology)
• Duck and Human Pandemic Influenza A Viruses Retain Sialidase Activity under Low pH Conditions^1
• A Macrocyclic Sialic Acid Cluster as a Host, as an Adsorbate, and as a Ligand for Lectin and Virus
• Ganglioside GM_ on the Cell Surface Is Involved in the Infection by Human Rotavirus KUN and MO Strains
• 新規硬化療法剤の細胞障害作用
• Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
• Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
• Thromboxane A_2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli
• Effect of DP - 1904, a Thromboxane A_2 Synthase Inhibitor, Administered from the Autologous Phase on Crescentic-Type Anti-GBM Nephritis in Rats
• Association study of the C3 gene with adult and childhood asthma
• Synthetic Studies on Selection Ligands/Inhibitors. Synthesis and Biological Evaluation of Sulfated and Phosphorylated β-D-Galacto- and Lactopyranosides Containing Fatty-Alkyl Residues of Different Carbon Chain Lengths
• SYNTHESIS AND BIOLOGICAL ACTIVITY OF THE NOVEL SULFATED AND PHOSPHORYLATED BIVALENT β-D-GALACTOPYRANOSIDES CONTAINING FATTY-ALKYL RESIDUES
• Resistance of Hepatic Lysosomes, Mitochondria and Microsomes of Protoporphyrin-Administered Rats to Peroxidative Damage
• Antioxidative Effect of Protoporphyrin and Increase of Glutathione in Protoporphyrin-Administered Rat Liver
• プロトポルフィリン投与ラットにおけるポルフィリンの肝細胞内分布と抗脂質過酸化作用(生物学及び生化学)
• ANTIOXIDATIVE EFFECT OF SEVERAL PORPHYRINS ON LIPID PEROXIDATION IN RAT LIVER HOMOGENATES
• Effects of Sodium Metallochlorophyllins on the Activity and Components of the Microsomal Drug-Metabolizing Enzyme System in Rat Liver
• Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. IX. : On the Antioxidative Components in Commercial Preparations of Sodium Copper Chlorohyllin
• Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. VIII. Its Effect on Carbon Tetrachloride-Induced Liver Injury in Rats
• Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. VII. Effect of Its Administration on the Stability of Rat Liver Lysosomes
• Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. VI. Effect of Its Administration on Mitochondrial and Microsomal Lipid Peroxidation in Rat Liver
• Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. V. Effect on Peroxidative Damage of Rat Liver Lysosomes
• 市販銅クロロフィリンナトリウム中の1抗酸化成分について
• Influenza A Virus-Binding Activity of Glycoglycerolipids of Aquatic Bacteria
• P-564 MULTI-DIMENSIONAL HPLC MAPPING METHOD FOR STRUCTURAL ANALYSES OF N-GLYCANS AND ITS APPLICATIONS TO N-GLYCOSYLATION PROFILING OF ORGANISMS AND TISSUES
• Platelet Anti-aggregant Activity of 2,2-Dimethylthiazolidine Hydrochloride and 2-(4-Hydroxy-3-methoxyphenyl)thiazolidine
• Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
• Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
• Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
• β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells
• The Transport of Ciprofloxacin in Cultured Kidney Epithelial Cells LLC-PK_1
• Role of Sialylglycoconjugate(s) in the Initial Phase of Metastasis of Liver-metastatic RAW117 Lymphoma Cells
• Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent(3): Effect of Acteoside on Expression of Intercellular Adhesion Molecule-1 in Experimental Nephritic Glomeruli in Rats and Cultured Endothelial Cells
• Suppression of Experimental Crescentic-Type Anti-Glomerular Basement Membrane (GBM) Nephritis by FK506 (Tacrolimus Hydrate) in Rats
• The Possible Roles of Hyperlipidemia and Mononuclear Cells in Glomeruli in Puromycin Aminonucleoside Nephrosis in Rats
• PRECLINICAL EVALUATION OF ANTINEPHRITIC DRUGS
• BENZYLIDENECYANOMETHYL-1,3-BENZAZOLES AS 1-AZA-1,3-BUTADIENES
• Association of the RIP2 Gene with Childhood Atopic Asthma
• Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
• Facile Synthesis of 5α-Fluorocholestan-3-one from 4-Cholesten-3-one via Molecular Fluorine Addition and Reductive Defluorination
• Catalytic Action of Azolium Salts. IX. Synthesis of 6-Aroyl-9H-purines and Their Analogues by Nucleophilic Aroylation Catalyzed by Imidazolium or Benzimidazolium Salt
• Carbon-Carbon Bond Cleavage of α-Hydroxybenzylheteroarenes Catalyzed by Cyanide Ion : Retro-Benzoin Condensation Affords Ketones and Heteroarenes and Benzyl Migration Affords Benzylheteroarenes and Arenecarbaldehydes
• Carbon-Carbon Bond Cleavage of α-Substituted Benzoins by Retro-Benzoin Condensation : A New Method of Synthesizing Ketones
• Catalytic Action of Azolium Salts. VIII. Oxidative Aroylation with Arenecarbaldehydes Catalyzed by 1,3-Dimethylbenzimidazolium Iodide
• A New Method of Synthesizing Deoxybenzoins from 1,3-Dimethyl-2-(α-benzyloxybenzyl)imidazolium and 1,3-Dimethyl-2-(α-benzyloxybenzyl)benzimidazolium Iodides Based on Wittig-Type Rearrangement
• Olefin-Insertion Reaction between the Carbonyls of Benzils ; Formation of 1, 4-Diketons by Michael Addition Catalyzed by Cyanide Ion
• SYNTHESIS OF KETONES BY RETRO-BENZOIN CONDENSATION CATALYZED BY POTASSIUM CYANIDE
• Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
• An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
• Enzymatic Preparation of Ginsenosides Rg_2, Rh_1, and F_1
• Effect of Protoporphyrin on Peroxidative Damage of Rat Liver Lysosomes
• Antioxidative Effect of Protoporphyrin on Lipid Peroxidation in Rat Liver Subcellular Fractions
• m-ジクロロベンゼン及びその含硫代謝物のマウス肝薬物代謝酵素系に及ぼす影響
• ラット肝可溶性画分存在下におけるミクロゾームの脂質過酸化におよぼすNADPHの影響
• Pharmacokinetics of Granisetron in Adults and Children with Malignant Diseases
• A Rapid Assay of Granisetron in Biological Fluids from Cancer Patients.
• A Rapid Assay of Granisetron in Biological Fluids from Cancer Patients
• Induction of Cyclooxygenase-2 Expression in Glomeruli by Aggregated Protein
• Z-335,a Thromboxane A_2 Receptor Antagonist, Suppresses the Progression of Arachidonic Acid-Induced Hind Limb Gangrene in Rats
• Arachidonic Acid-Induced Hind Limb gangrene : A New Experimental Rat Model of Paripheral Vascular Disease
• New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
• New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
• Modulation of Anti-Glomerular Basement Membrane Nephritis in Rats by ONO-1301, a Non-Prostanoid Prostaglandin I_2 Mimetic Compound with Inhibitory Activity against Thromboxane A_2 Synthase
• Effects of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse), on Postoperative Ileus in Dogs after Laparotomy
• Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (III) : Feto-Placental Transfer and Excretion into Milk in Rats after Single Intravenous Injection of^3H-SK-896
• Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (II) : Blood and Plasma Concentration and Excretion in Rats after Single Intravenous Injection or Constant Rate Intravenous Infusion of ^3H-SK-896
• Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (I) : Distribution and Accumulation in Rats after Single or Repeated Intravenous Injection of ^3H-SK-896
• Anti-ulcer Effects of Antioxidants, Quercetin, a-Tocopherol, Nifedipine and Tetracycline in Rats
• Sex Differences in Constitutive Level of Renal Lauric Acid Hydroxylase Activities and CYP4A-Related Proteins in Mice
• Sex and Strain Differences in Constitutive Expression of Fatty Acid ω-Hydroxylase (CYP4A-Related Proteins) in Mice
• Simultaneous Evaluation of Gastric and Duodenal Ulcers-Healing Activities of Anti-ulcer Agents in Rats
• Effects of Gonadectomy and Sex Hormones on the Induction of Hepatic CYP4A by Clofibrate in Rats
• Healing-Promoting Action of the Zinc-Cimetidine Complex on Acetic Acid-Induced Gastric Ulcers in Rats
• Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin
• In Vivo Drug Release and Antitumor Characteristics of Water-Soluble Conjugates of Mitomycin C with Glycol-Chitosan and N-Succinyl-Chitosan
• Preparation and Drug Release Characteristics of the Conjugates of Mitomycin C with Glycol-chitosan and N-Succinyl-chitosan
• Butein Ameliorates Experimental Anti-Glomerular Basement Membrane (GBM) Antibody-Associated Glomerulonephritis in Rats (1)
• Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study
• Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus
• A genome-wide association study identifies RNF213 as the first Moyamoya disease gene
• Association of the MMP9 gene with childhood cedar pollen sensitization and pollinosis
• Replication of genetic association studies in asthma and related phenotypes

もっと見る 閉じる

スポンサーリンク