製剤中のニトロプルシドナトリウム定量法に関する検討 : 直接吸光度法,スルフィド法,高速液体クロマトグラフ法についての検討

概要

論文の詳細を見る
The evaluation of methods for quantitative analysis of sodium nitroprusside (SNP), a potent hypotensive agent, is described. The direct spectrophotometrical method described by M.J. Frank et al., which has been employed as a conventional method in the hospital had a liability to overestimate the degradation of SNP. The high-performance liquid chromatographic method reported by O.R. Leeuwenkamp et al., with some modification gave accurate value and showed two peaks on chromatogram assignable to degradation products. The sulfide method reported by C.J. Vesey and G.A. Batistoni was thought to be a simple and convenient method for the quantitative estimation of degradation of SNP. Photodegradation was dependent upon the concentration of SNP. Higher degradation rate was observed in lower concentration. The difference in the extent of degradation was not found for solvents used, distilled water, 5% glucose solution and 0.9% saline solution. The degradation of an aqueous solution of SNP stored in a cool and dark place for 13 months was not observed.
日本医療薬学会の論文
1989-10-20