Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. VII. Effect of Its Administration on the Stability of Rat Liver Lysosomes

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The effect of administration of sodium copper chlorophyllin (Cu-Chl-Na), a mixture of copper chelates of chlorophyll derivatives, on the peroxidative and hypo-osmotic fragility of lysosomes was investigated using the lysosome-containing (3500×g) fraction of rat liver. When Cu-Chl-Na was given by i.p. injection 24h prior to sacrifice, both ascorbic acid-induced lipid peroxidation in 3500×g fraction and the concomitant release of acid phosphatase and aryl sulfatase from lysosomes were inhibited to similar extents. These inhibitory effects were correlated with the content of Cu-Chl-Na or substance (s) derived from Cu-Chl-Na in the 3500×g fraction. Further, the administration of Cu-Chl-Na significantly depressed the release of the two lysosomal enzymes caused by the incubation of 3500×g fraction in 0.18 M sucrose medium. These results suggest that Cu-Chl-Na may function in vivo as a membrane stabilizer of liver lysosomes through its antioxidative and direct actions on the lysosomal membranes.
社団法人日本薬学会の論文
1984-07-25