Influence of Alkylamides of Glutamic Acid and Related Compounds on the Central Nervous System. I. Central Depressant Effect of Theanine

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Theanine (N-ethylglutamine), a flavourous constituent of tea leaves, was studied in respect of the influence on the central nervous system in mice. Theanine was shown to inhibit the convulsive action of caffeine, but was ineffective against pentetrazole, picrotoxin, strychnine, pipradrol and bemegride as well as L-glutamine. Neither theanine nor L-glutamine effected on the prolongation of the sleeping time after the injection of hexobarbital sodium in mice. Using ^<14>C-labeled theanine, it was found that the intraperitoneally administered theanine was taken up by brain tissue without undergoing the metabolic changes in a 30 minutes. The intracerebral level of γ-aminobutyric acid was shown to increase significantly at 30 minutes following the intraperitoneal administration of theanine in mice.
公益社団法人日本薬学会の論文
1971-06-25