Butyrophenone系薬物に関する生物薬剤学的研究(第3報)Clofluperolのラットにおける体内動態

概要

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Disposition of ^3H-labelled clofluperol (^3H-CLO) following oral dosage was studied in Wistar male and female rats. Urinary and biliary excretion of ^3H was greater in males than in females, while tissue radioactivity examined was, in general, somewhat higher in females than in males. Only a small amount of unchanged CLO was excreted in urine, bile and feces, and the major urinary metabolite of CLO was identified as p-fluorophenaceturic acid. Selective accumulation and prolonged retention of radioactivity were observed in the exocrine and endocrine glands such as salivary gland, pancreas, adrenal and ovary, and in the liver and kidney. Most tissue radioactivity in male rats tested was found in the unchanged CLO fraction. In regional distribution study of CLO in male rat brains, radioactivity was evenly distributed except for the pituitary in which comparatively high radioactivity was found during the initial 4 hr after administration.
社団法人日本薬学会の論文
1979-06-25