水生生物におよぼすPCBの影響-IV : PCB経口投与によるコイの血清脂質量の変化ならびに組織の脂質過酸化物について

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Changes in the levels of several serum lipid components and the formation of lipid peroxides in hepatopancreas, kidney and the dark muscle of carp, Cyprinus carpio, fed with a diet containing PCB (Aroclor 1248) at 250ppm were examined. After feeding with the PCB-containing diets for 7, 14 or 21 days, the carps were sacrificed for chemical analyses.Triglyceride, total cholesterol, free cholesterol and free fatty acid contents were increased, while the ester to total cholesterol ratio was decreased in the PCB fed group. Especially, the triglyceride levels in carps fed with PCB showed substantial increases, more than 30%, compared with those of the control fishes.The thiobarbituric acid reactive compounds were shown to increase in the hepatopancreas and the dark muscle with the administered dosage of PCB. In the difference spectrum of hepatopancreal lipid, the diene conjugation absorption appeared after feeding for 14 days.Furthermore, the lipid metabolism in carp fed with the diet containing PCB is discussed, indicating the possibility of lipid peroxide formation in subcellular membranes.
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