銅クロロフィリンナトリウムの脂質過酸化反応におよぼす影響(第2報)ラット肝ホモジネート脂質および遊離不飽和脂肪酸の過酸化に対する影響
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概要
- 論文の詳細を見る
Effect of sodium copper chlorophyllin (SCC) on the peroxidation of lipids in rat liver homogenates and of the free unsaturated fatty acids were studied. SCC showed an inhibitory effect on the lipid peroxidation in liver homogenates which was induced by Fe^<2+>, Tween 80,or UV-irradiation. Peroxidation of a mixture of linolenic and linoleic acids was estimated by the oxygen consumption, thiobarbituric acid value, and peroxide value, and SCC was found to depress the production of peroxides from the free unsaturated fatty acids. SCC was found to be as effective as α-tocopherol in reducing 1,1-diphenyl-2-picrylhydrazyl which was used as a model compound for the free radical formed in the peroxidation of unsaturated fatty acid. From these findings, it was assumed that the antioxidative effect of SCC might be due to its reaction with the free radicals formed along with lipid peroxidation.
- 公益社団法人日本薬学会の論文
- 1977-02-28
著者
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村田 敏郎
静岡薬科大学
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佐藤 正基
School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation
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村田 敏郎
School of Pharmaceutical Science, University of Shizuoka
-
佐藤 正基
静岡薬科大学
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井口 ナチ子
静岡薬科大学
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小谷 友香
静岡薬科大学
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