Synthesis and Platelet Aggregation Inhibitory Activities of 3-(2-Oxopropylidene)azetidin-2-one Derivatives. II
スポンサーリンク
概要
- 論文の詳細を見る
A series of 3-acylidene-4-methylazetidine-2-one derivatives bearing various substituents at the 1-position of the azetidin-2-one ring was synthesized. These compounds were evaluated for platelet aggregation inhibitory activities. Most of the compounds synthesized showed potent inhibitory activities against rabbit platelet aggregation induced by adenosine diphosphate or collagen in vitro. Structure-activity relationships are also discussed.
- 社団法人日本薬学会の論文
- 1991-12-25
著者
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佐藤 正和
成均館大学校
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佐藤 正和
大正製薬
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川島 豊
Research Center, Taisho Pharmaceutical Co., Ltd.
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佐藤 正和
Research Center, Taisho Pharmaceutical Co., Ltd.
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畑田 祐一
Research Center, Taisho Pharmaceutical Co., Ltd.
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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五藤 准
Research Center Taisho Pharm. Co., Ltd.,
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山根 裕子
Research Center Taisho Pharm. Co., Ltd.,
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川島 豊
Research Center Taisho Pharmaceutical Co. Ltd.
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川島 豊
大正製薬・総合研
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畑田 祐一
Research Center Taisho Pharmaceutical Co. Ltd.
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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佐藤 正基
School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation
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Satoh M
Showa Pharmaceutical Univ. Tokyo Jpn
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Sato M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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五藤 准
Research Center Taisho Pharm. Co. Ltd.
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佐藤 真友美
Univ. Shizuoka Shizuoka Jpn
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佐藤 正和
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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山根 裕子
Research Center Taisho Pharm. Co. Ltd.
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畑田 祐一
Research Center, Taisho Pharmaceutical Co., Ltd.,
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