Anti-ulcer Effect of Isoprenyl Flavonoids. III. Synthesis and Anti-ulcer Activity of Metabolites of 2'-Carboxymethoxy-4,4'-bis (3-methyl-2-butenyloxy) chalcone
スポンサーリンク
概要
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Five dihydrochalcone derivatives, 2'-carboxymethoxy-4,4'-bis (3-methyl-2-butenyloxy) dihydrochalcone (M-6-b), 2', 4-bis (carboxymethoxy)-4'-(3-methyl-2-butenyloxy) dihydrochalcone (M-2), 2', 4-bis (carboxymethoxy)-4'-(3-carboxy-2-butenyloxy) dihydrochalcone (M-1-a), 2', 4-bis (carboxymethoxy)-4'-(3-hydroxymethyl-2-butenyloxy) dihydrochalcone (M-1-b), and 2'-carboxymethoxy-4-hydroxy-4'-(3-methyl-2-butenyloxy) dihydrochalcone (M-4-b), which are the main metabolites in rats of a new anti-ulcer drug "sofalcone"(2'-carboxymethoxy-4,4'-bis (3-methyl-2-butenyloxy) chalcone) were synthesized and the anti-ulcer activities of the major metabolites in humans, M-6-b, M-2,and M-1-a, were examined by Shay's and Takagi's methods and also by the use of rats with histamine-induced ulcer. The most active compound was M-6-b, which showed activity equal to or slightly weaker than that of sofalcone.
- 公益社団法人日本薬学会の論文
- 1985-04-25
著者
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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川島 豊
Research Center Taisho Pharmaceutical Co. Ltd.
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川島 豊
大正製薬・総合研
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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佐直 隆一
大正製薬株式会社 総合研究所
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京極 和旭
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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横森 貞和
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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佐直 隆一
Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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横森 貞和
Research Center Taisho Pharmaceutical Co. Ltd.
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佐直 隆一
Research Center Taisho Pharmaceutical Co. Ltd.
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京極 和旭
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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