Structure-Activity Study of Antihypertensive 1,4-Dihydropyridine Derivatives Having Nitrooxyalkyl Moieties at the 3 and 5 Positions
スポンサーリンク
概要
- 論文の詳細を見る
1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4-dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.
- 社団法人日本薬学会の論文
- 1993-06-15
著者
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広野 修一
北里大学薬学部
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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川島 豊
Research Center Taisho Pharmaceutical Co. Ltd.
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川島 豊
大正製薬・総合研
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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土田 勝晴
Research Center Taisho Pharmaceutical Co. Ltd.
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広野 修一
Department Of Pharmaceutical Sciences Kitasato University
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森口 郁生
School Of Pharmaceutical Sciences Kitasato University
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中里 篤郎
Research Center Taisho Pharmaceutical Co. Ltd.
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加藤 美幸
Research Center Taisho Pharmaceutical Co. Ltd.
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広野 修一
School of Pharmaceutical Sciences, Kitasato University
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小川 利寿
Research Center, Taisho Pharmaceutical Co., Ltd.,
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森口 郁生
北里大
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小川 利寿
Research Center Taisho Pharmaceutical Co. Ltd.
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Moriguchi I
School Of Pharmaceutical Sciences Kitasato University
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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