Structure-Activity Study of Antihypertensive 1,4-Dihydropyridine Derivatives Having Nitrooxyalkyl Moieties at the 3 and 5 Positions
スポンサーリンク
概要
- 論文の詳細を見る
1,4-Dihydropyridine derivatives having two nitrooxyalkyl moieties as esters at the 3 and 5 positions possess antihypertensive activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) of 27 compounds was analyzed using the Fuzzy adaptive least-squares (FALS 91) method. The QSAR models suggested that the hydrophobicity and electronic effect at the 4 position of the 1,4-dihydropyridine along with the special structures of the nitrooxyalkylester components are important for antihypertensive activity.
- 社団法人日本薬学会の論文
- 1993-06-15
著者
-
広野 修一
北里大学薬学部
-
畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
-
川島 豊
Research Center Taisho Pharmaceutical Co. Ltd.
-
川島 豊
大正製薬・総合研
-
畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
-
土田 勝晴
Research Center Taisho Pharmaceutical Co. Ltd.
-
広野 修一
Department Of Pharmaceutical Sciences Kitasato University
-
森口 郁生
School Of Pharmaceutical Sciences Kitasato University
-
中里 篤郎
Research Center Taisho Pharmaceutical Co. Ltd.
-
加藤 美幸
Research Center Taisho Pharmaceutical Co. Ltd.
-
広野 修一
School of Pharmaceutical Sciences, Kitasato University
-
小川 利寿
Research Center, Taisho Pharmaceutical Co., Ltd.,
-
森口 郁生
北里大
-
小川 利寿
Research Center Taisho Pharmaceutical Co. Ltd.
-
Moriguchi I
School Of Pharmaceutical Sciences Kitasato University
-
Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
関連論文
- Clinical Estimation of Vancomycin Measurement Method on Hemodialysis Patient
- 塩酸バンコマイシン(VCM)のレトロスペクティブな使用実態調査による副作用・有効性に影響を及ぼす因子の検討
- Furo[3,2-b]indole Derivatives. V. Synthesis and Structure-Activity Studies of 4-Substituted 2-(4-Methylpiperazinylcarbonyl)-6-trifluoromethylfuro[3,2-b]indole Derivatives with Analgesic and Antiinflammatory Activities(Medicinal Chemistry,Chemical)
- Structure-Activity Relationship Study of TXA_2 Receptor Antagonists. 4-[2-(4-Substituted Phenylsulfonylamino)ethylthio]phenoxyacetic Acids and Related Compounds
- Synthesis and Evaluation of Novel Thiazolidine Derivatives as Thromboxane A_2 Receptor Antagonists
- Synthesis and Platelet Aggregation Inhibitory Activities of 3-(2-Oxopropylidene)azetidin-2-one Derivatives. II
- Synthesis and Platelet Aggregation-Inhibitory Activities of Novel 3-(2-Oxopropylidene)azetidin-2-one Derivatives. I
- Furo[3,2-b]indole Derivatives. VI. Synthesis and Inhibitory Effect on Platelet Aggregation of Furo[3,2-b]indole Derivatives(Medical Chemistry,Chemical)
- Furo[3,2-b]indole Derivatives. III. : Structure-Activity Studies of 4,6-Disubstituted N-(3-Piperidinopropyl)furo[3,2-b]indole-2-carboxamide Derivatives for Analgesic and Antiinflammatory Activities
- Furo [3,2-b] indole Derivatives. II. Synthesis and Analgesic and Anti-inflammatory Activities of 4-Alkoxycarbonyl-2-morpholinocarbonylfuro [3,2-b] indole Derivatives
- 鎮痛・抗炎症活性を示すフロ-インド-ルカルボン酸アミドの定量的構造活性相関とドラッグデザイン (構造活性相関とドラッグデザイン)
- アンジオテンシンII変換酵素阻害薬オルメサルタンメドキソミルのヒト血清アルブミンによる加水分解及びその触媒部位の同定(発表論文抄録(2006))
- 構造生物学と創薬の現状と課題そして将来
- Furo [3,2-b] indole Derivatives. I. Synthesis and Analgesic and Anti-inflammatory Activities of 4,6-Disubstituted-furo [3,2-b] indole-2-carboxamide Derivatives
- 1P045 タンパク質-リガンド複合体予測構造の分子シミュレーションによる評価(蛋白質(機能),ポスター発表,第45回日本生物物理学会年会)
- Electrostatic Potential Images of Drugs Targetting Dopamine Receptors
- A Molecular Orbital Study on Tetranactin-NH_4+ Complex
- A Molecular Orbital Study on the n-π^* Cotton Effect of ε-Caprolactam
- Purification and Properties of Z Protein from Rabbit and Rat Liver
- In Vitro Binding of Sulfobromophthalein to Cytoplasmic Protein from Liver, Kidney, and Small Intestinal Mucosa of Rat and Rabbit
- Structure-Activity Study of Antihypertensive 1,4-Dihydropyridine Derivatives Having Nitrooxyalkyl Moieties at the 3 and 5 Positions
- Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Derivatives Containing Nitrooxyalkylester Moieties at the 3- and 5-Positions
- Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Derivatives Containing a Nitrooxy Moiety at the 3-Ester Position
- J60 単環式フェノール系化合物のゴキブリ誘引摂食活性について(生理活性物質)
- Non-congeneric Structure-Pharmacokinetic Property Correlation Studies Using Fuzzy Adaptive Least-Squares : Volume of Distribution
- Comparison of Reliability of log P Values for Drugs Calculated by Several Methods
- Non-congeneric Structure-Pharmacokinetic Property Correlation Studies Using Fuzzy Adaptive Least-Squares : Oral Bioavailability
- Platelet Anti-aggregant Activity of 2,2-Dimethylthiazolidine Hydrochloride and 2-(4-Hydroxy-3-methoxyphenyl)thiazolidine
- Studies on Topical Antiinflammatory Agents. IV., : 21-(Alkylthio)acetates and (Methylthio)methoxides of Corticosteroids
- Studies on Topical Antiinflammatory Agents. V. : 17-(Alkylthio)- and Methoxyalkanoates of Corticosteroids
- Studis on Topical Antiinflammatory Agents. III. : Synthesis of 17α-Acyloxy-9α-fluoro-11β-hydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-Thio Dericatives and Related Compounds
- Studies on Topical Antiinflammatory Agents. II. Synthesis and Vasoconstrictive Activity of 21-Substituted Corticosteroids with Sulfur-Containing Moieties
- 1J1330 ペンタクロロフェノール分解酵素PcpBの立体構造モデリングと酵素反応機構の解析(1.蛋白質(A)構造,一般演題,日本生物物理学会第40回年会)
- PPARδ選択的アゴニストの創製と受容体-リガンド複合体構造情報を踏まえた選択性発現機構解明
- Constituents of Chinese Crude Drug "Kushen"(the Root of Sophora flavescens AIT.). Isolation of Five New Flavonoids and Formononetin
- Studies on the Constituents of Guang-Dou-Gen (the Root of Sophora subprostrata CHUN et T.CHEN). (6). Isolation of Two New Flavanones
- Studies on the Constituents of Guang-Dou-Gen (the Root of Sophora subprostrata CHUN et T.CHEN). (5). Isolation of Two New Flavanones and Daidzein
- Bufadienolides. IX. Isolation and Structure of Resibufagin
- Studies on the Constituents of Sophora Species. V. Constituents of the Root of Sophora angustifolia SIEB. et ZUCC. (2)
- Studies on the Constituents of Sophora Species. II. Constituents of Sophora subprostrata CHUN et T. CHEN. (2). Isolation and Structure of New Flavonoids, Sophoradochromene and Sophoranochromene
- Studies on the Constituents of Sophora Species. I. Constituents of Sophora subprostrata CHUN et T. CHEN. (1). Isolation and Structure of New Flavonoids, Sophoradin and Sophoranone
- Structures of New Flavonoids, Sophoradochromene and Sophoranochromene, from Sophora subprostrata
- Structures of New Flavonoids, Sophoradin and Sophoranone, from Sophora subprostrata
- Studies on Selectivity of O-Methylation of Erythromycin Derivatives Based on Molecular Mechanics and Molecular Orbital Methods
- Structure-Activity Relationship Study of 6-O-Methylerythromycin 9-O-Substituted Oxime Derivatives
- 24 エリスロマイシン誘導体のO-メチル化における位置選択性について(口頭発表の部)
- NMR測定と計算化学手法を組み合わせたタンパク質-薬物相互作用の解析
- Computer-Aided Structure-Based Drug Design入門 : 創薬におけるBioinformaticsの応用
- Computer-Aided Rational Drug Design 入門
- イン・シリコ創薬技術に基づく合理的薬剤分子設計
- 創薬のための電荷平衡法 (特集 電荷平衡法による機能材料設計)
- 電荷平衡法へのatom typeの導入と新たなパラメータの算出
- Solvation Free Energies of Amino Acids Calculated by Molecular Dynamics/Free Energy Perturbation Method
- SOLUTION STRUCTURE OF HIV-1 PROTEASE-ALLOPHENYLNORSTATINE DERIVATIVE INHIBITOR COMPLEX OBTAINED FROM MOLECULAR DYNAMICS SIMULATION
- 構造活性相関による毒性予測
- Comparison of the Functional-Link Net and the Generalized Delta Rule Net in Quantitative Structure-Activity Relationship Studies
- Fuzzy Adaptive Least Squares Applied to Structure-Activity and Structure-Toxicity Correlations
- Structure-Activity Studies of 3-Benzoylpropionic Acid Derivatives Suppressing Adjuvant Arthritis
- Simple Method of Calculating Octanol/Water Partition Coefficient
- High Correlation between Hydrophobic Free Energy and MOlecular Surface Area Characterized by Electrostatic Potential
- 生体高分子系におけるコンピュータシミュレーションの新展開
- Fuzzy Adaptive Least Squares and Its Use in Quantitative Structure-Activity Relationships
- Quantitative Structure-Activity Relationships for Calmodulin Inhibitors
- 20aPS-115 タンパク質-リガンド複合体構造を利用した配座解析手法の比較(20aPS 領域12ポスターセッション,領域12(ソフトマター物理,化学物理,生物物理))
- 24aPS-103 GAFF力場による配座解析の精度評価(領域12ポスターセッション,領域12,ソフトマター物理,化学物理,生物物理)
- 1K0900 Cytochrome P450の鉄-ポルフィリンモデル系の構造と原子電荷に関する理論的研究(2.ヘム蛋白質,一般演題,日本生物物理学会第40回年会)
- 1P196タンパク質1次構造の最適アライメント探索のためのAnt Colony Optimizationの開発
- Quantitative Structure-Activity Relationships of O-Acyl Derivatives of Leucomycin for Antimicrobial and Ribosome-Binding Activities
- Structure-based drug designのための分子動力学シミュレ-ション (特集 創薬研究とコンピュ-タ-科学(Part 1))
- コンピュ-タによるドラッグデザインの新展開 (特集 情報化学とコンピュ-タケミストリ-)
- 26-A5-01 塩酸バンコマイシンの副作用及び有効性に影響を及ぼす因子の検討
- Binding of Carprofen to Human and Bovine Serum Albumins
- Anti-ulcer Effect of Isoprenyl Flavonoids. II. Synthesis and Anti-ulcer Activity of New Chalcones related to Sophoradin
- Synthesis and Antiinflammatory Activity of Alkenylphenylpropionic Acids
- Synthesis and Pharmacological Evaluation of 1,2,3,4-Tetrahydro-β-carboline Derivatives
- Mild and Facile Cleavage of 2-Cyanoethyl Ester Using Sodium Sulfide or Tetrabutylammonium Fluoride. Synthesis of 1,4-Dihydropyridine Monocarboxylic Acids and Unsymmetrical 1,4-Dihydropyridine Dicarboxylates
- Protecting Group for Carboxyl Function : Mild and Facile Cleavage of 2-Cyanoethyl Ester under Non-hydrolytic Conditions
- Anti-ulcer Effect of Isoprenyl Flavonoids. III. Synthesis and Anti-ulcer Activity of Metabolites of 2'-Carboxymethoxy-4,4'-bis (3-methyl-2-butenyloxy) chalcone
- Estimation of Hydrophobicity Based on the Solvent-Accessible Surface Area of Molecules
- Studies on the Constituents of Sophora Species. VI. Constituents of the Root of Sophora subprostrata CHUN et T. CHEN. (4)
- Application of Quenching of Albumin-Induced Fluorescence of 8-Anilinonaphthalene-1-sulfonate to the Studies on Protein Bindings and Protein-Mucopolysaccharide Interaction
- Studies on Protein Bindings utilizing Quenching of Albumin-Induced Fluorescence of 8-Anilinonaphthalene-1-sulfonate
- Binding of Drugs to Sera of Patients with Renal Disease and Liver Disease(Pharmaceutical)
- In Silico 創薬技術に基づく Structure-Based Drug Design (SBDD) の実際
- Computer-Aided Rational Drug Design 入門(21 世紀の創薬手法)
- Complexation of Chlorpromazine with Adenosine and Its Phosphates
- Effect of Water on Rate of Charge-Transfer Reaction of Aniline with Chloranil
- Effect of Water on Charge-Transfer Complexations
- Solvent Effects on π-π Charge-Transfer Complexations
- Spectral Changes of Various Dyes by Bovine Serum Albumin and by Organic Solvents
- Spectroscopic Studies on Molecular Interactions. VI. Mechanism of Metachromasy of 2-(4'-Hydroxyphenylazo) benzoic Acid by Serum Albumin
- Spectroscopic Studies on Molecular Interactions. V. Charge-Transfer Property and Enzymatic Acetylation of Aniline Derivatives
- Adsorption of Solute from the Solutions. IV. Adsorption of Benzoic Acids on Graphite
- Adsorption of Solute from the Solutions. V. Adsorption Rate of Cyanocobalamin on Talc
- Spectroscopic Studies on Molecular Interactions. IV. Charge-Transfer Properties and Antibacterial Activity of Sulfonamides
- Spectroscopic Studies on Molecular Interactions. III. Improvement of the Benesi-Hildebrand Method for the Determination of Equilibrium Constants
- Spectroscopic Studies on Molecular Interactions. II. Complexation between Polyvinylpyrrolidone and Iodine
- Spectroscopic Studies on Molecular Interactions. I. Complexations between Caffeine and Benzoic Acids
- Adsorption of Solute from the Solutions. III. Repression of Adsorption of Cyanocobalamin on Talc by Polyvinylpyrrolidone
- AQUATIC TOXICITY. : A PREDICTIVE STRUCTURE-ACTIVITY MODEL