Bufadienolides. IX. Isolation and Structure of Resibufagin
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概要
- 論文の詳細を見る
A new bufadienolide, resibufagin (I), has been isolated from both"thin-plate"Ch'an Su and"disk-like"one. Based on the chemical and spectral evidence, the structure of resibufagin (I) was assigned to be 3β-hydroxy-19-oxo-14β, 15β-epoxy-5β-bufa-20,22-dienolide. Treatment of I with sodium borohydride afforded an alcohol, named resibufaginol (III). Oxidation of an acetate (II) obtained from I with chromium trioxide gave a corresponding 10-carboxylic acid (V), which was methylated to afford a 10-methyl carboxylate (VI). Treatment of I or II with hydroxylamine hydrochloride and sodium acetate gave the corresponding oxime, VII or VIII, respectively. Acetylation of VII or VIII with acetic anhydride and pyridine afforded the same acetyloxime (IX). Furthermore, together I, there were obtained a bufogenin, which was identified to be marinobufagin (X), first isolation from Ch'an Su. Resibufagin (I) isolated from Ch'an Su is the third bufadienolide having 10-formyl group. Also resibufaginol (III) obtained from I is the third bufadienolide having 10-alcohol group, and may be obtained from toad venoms on further examination.
- 公益社団法人日本薬学会の論文
- 1971-12-25
著者
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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畑山 勝男
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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釜野 徳明
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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小松 曼耆
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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小松 曼耆
Research Laboratory Taisho Pharmaceutical Co. Ltd.:(present Address)faculty Of Pharmaceutical Scienc
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篠原 道子
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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釜野 徳明
Research Laboratories Taisho Pharmaceutical Co. Ltd.
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釜野 徳明
アリゾナ州立大学ガン研
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篠原 道子
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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釜野 徳明
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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