Studies on Topical Antiinflammatory Agents. II. Synthesis and Vasoconstrictive Activity of 21-Substituted Corticosteroids with Sulfur-Containing Moieties
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概要
- 論文の詳細を見る
As part of the search for new topical antiinflammatory agents, various 21-substituted corticosteroids having sulfur-containing moieties were prepared and tested for vasoconstrictive activity in humans. A structure-activity relationship study revealed that substitution of the 21-hydroxy group with a lower alkyl-thio group enhanced the activity. The activities of the 21-methylthio (3Ad) and the 21-ethylthio (3Ae) compounds were more potent than that of 9α-fluoro-11β, 21-dihydroxy-16β-methyl-17α-valeroyloxy-1,4-pregnadiene-3,20-dione (betamethasone 17-valerate, BV).
- 公益社団法人日本薬学会の論文
- 1989-07-25
著者
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安井 一
Research Center Taisho Pharmaceutical Co. Ltd.
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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曽田 馨
Research Center, Taisho Pharmaceutical Co., Ltd.
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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樋口 昭平
Research Center Taisho Pharmaceutical Co. Ltd.
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三口 守公
Research Center, Taisho Pharmaceutical Co., Ltd.,
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池本 知之
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田口 稔
Research Center, Taisho Pharmaceutical Co., Ltd.,
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阿部 訓志
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田口 稔
Research Center Taisho Pharmaceutical Co. Ltd.
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池本 知之
Research Center Taisho Pharmaceutical Co. Ltd.
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三口 守公
Research Center Taisho Pharmaceutical Co. Ltd.
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曽田 馨
Research Center Taisho Pharmaceutical Co. Ltd.
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阿部 訓志
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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