Studies on Topical Antiinflammatory Agents. I. ; Synthesis and Vasoconstrictive Activity of Corticosteroid 17-Succinyl Esters
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概要
- 論文の詳細を見る
A series of 17-succinyl derivatives of four corticosteroids was prepared. They were tested for vasoconstrictive activity in humans, using 9α-fluoro-11β, 21-dihydroxy-16β-methyl-17α-valeryloxy-1,4-pregnediene-3,20-dione (betamethasone 17-valerate, BV) as a standard. The activities of the 21-chloro 17-methylsuccinate compounds (6A, 6C and 6D) were greater than that of BV. A structure-activity relationship study showed that the activities of the 21-chloro 17-methylsuccinates were more potent than those of the corresponding 21-esters.
- 公益社団法人日本薬学会の論文
- 1989-06-25
著者
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安井 一
Research Center Taisho Pharmaceutical Co. Ltd.
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曽田 馨
Research Center, Taisho Pharmaceutical Co., Ltd.
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樋口 昭平
Research Center Taisho Pharmaceutical Co. Ltd.
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三口 守公
Research Center, Taisho Pharmaceutical Co., Ltd.,
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池本 知之
Research Center, Taisho Pharmaceutical Co., Ltd.,
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中神 浄二
Research Center, Taisho Pharmaceutical Co., Ltd.,
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樽本 保男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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池本 知之
Research Center Taisho Pharmaceutical Co. Ltd.
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三口 守公
Research Center Taisho Pharmaceutical Co. Ltd.
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中神 浄二
Research Center Taisho Pharmaceutical Co. Ltd.
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樽本 保男
大正製薬株式会社 開発研究所
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曽田 馨
Research Center Taisho Pharmaceutical Co. Ltd.
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安井 一
Research Center, Taisho Pharmaceutical Co., Ltd.,
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