Hydrocortisone 17-butyrate 21-propionate の毒性研究 : 1. Hydrocortisone 17-butyrate 21-propionate 及びその類縁化合物の急性毒性試験

概要

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The acute toxicity of hydrocortisone 17-butyrate 21-propionate (HBP), hydrocortisone 17-butyrate (HB_<17>) and hydrocortisone 21-butyrate (HB_<21>) were investigated by three administration routes (s.c., i.p. and p.o.) in mice, rats and dogs. In the case of HBP, LD_<50> by oral administration was the highest, and followed by subcutaneous and intraperitoneal administration in mice and rats. And LD_<50> of HB_<17> and HB_<21> were not different from HBP in mice by subcutaneous administration. The deppression of spontaneous movement and respiratory rate, ptosis, larcrymation and the collapse were commonly observed in all drugs, and it was independent of administration routes. The autopsy revealed the atrophy of thymus, spleen and adrenal glands, the supprative nodules of heart and liver and the ulcers of alimentary tract in mice and rats. But the changes observed in mice and rats were recognized when 1000 mg/kg of HBP was administered to dogs subcutaneously. Many of these changes were common to glucocorticoids, and the LD_<50> of HBP was rather high compaired with other synthetic steroids ; therefore, HBP was among less toxic steroid.
日本トキシコロジー学会の論文
1981-07-25