Syntheses, Antitumor Activity and Vascular Relaxing Effect of Purino[7,8-g]-6-azapteridines and [1,2,4]Triazino-[3,2-f]purines(Organic,Chemical)
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概要
- 論文の詳細を見る
Novel heterocycles, purino[7,8-g]-6-azapteridines and [1,2,4]triazino[3,2-f]purines, were synthesized and their biological activities were examined. Heating of 7,8-diamino-1,3-dimethylxanthine (2), which was obtained by the reaction of 8-aminotheophylline with hydroxylamine-O-sulfonic acid, with hydrochloric acid gave 2,4,7,9-tetramethylpurino[7,8-g]-6-azapteridine-1,3,8,10(2H,4H,7H,9H)-tetrone (4) in 96% yield; this product was identical with the compound obtained by the reaction of 2 with alloxan followed by methylation. Treatment of 4 with alkylamines gave 3-alkylamino-2-alkylcarbamoyl-6,8-dimethyl[1,2,4]triazino[3,2-f]purine-7,8(6H,8H)-diones (10a-g) in 63-95% yields. Compound 4 was active against P388 leukemia. Vascular relaxing effects of some of the triazino[3,2-f]purines (10a,b,e,f) were examined, but none showed potent activity.
- 公益社団法人日本薬学会の論文
- 1987-10-25
著者
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植田 泰誠
Faculty of Pharmaceutical Sciences, Nagoya City University
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榊原 仁作
名市大院薬
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榊原 仁作
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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榊原 仁作
Nagoya City Univ. Nagoya Jpn
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浅野 正久
Department of Pharmacology, Nagoya City University Medical School
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浅野 正久
Department Of Pharmacology Nagoya City University Medical School
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中神 浄二
Research Center, Taisho Pharmaceutical Co., Ltd.,
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中神 浄二
Research Laboratories Taisho Pharmaceutical Co. Ltd.
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中神 浄二
Research Center Taisho Pharmaceutical Co. Ltd.
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安達 恒康
Faculty of Pharmaceutical Sciences, Nagoya City University
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植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
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安達 恒康
Faculty Of Pharmaceutical Sciences Nagoya City University
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榊原 仁作
Faculty Of Pharmaceutical Sciences Nagoya City University
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