Studies on the Chemical Modification of Monensin. I. : Synthesis and Crystal Stuructures of NaBr Complexes of Monensylamino Acids

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概要

• 論文の詳細を見る

• Condensation of the polyether antibiotic monensin (1) with amino acid benzyl esters followed by debenzylation gave monesylamino acids (3a-g), which were subsequently converted to the corresponding NaBr complexes (4a-g). An X-ray crystallographic study on 4e clarified that the conformation of 4e differs from that of the NaBr complex of monensin (5) in that an intramolecular hydrogen bond is present between O(3) oxygen and O(11) hydroxy proton. This finding is consistent with the carbon-13 nuclear magnetic resonance signals of the methoxy carbons of 4a-g which appear downfield relative to those of 3a-g. Compounds 3a-g showed no anticoccidial activity.

• 社団法人日本薬学会の論文
• 1988-12-25

著者

• 植田 泰誠

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 永井 慎一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 石田 寿昌

  Osaka University of Pharmaceutical Sciences

• 中村 明人

  Faculty Of Pharmaceutical Sciences

• 榊原 仁作

  名市大院薬

• 榊原 仁作

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 榊原 仁作

  Nagoya City Univ. Nagoya Jpn

• 永井 慎一

  名市大薬

• 植田 泰誠

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 榊原 仁作

  Faculty Of Pharmaceutical Sciences Nagoya City University

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