Synthesis of Polycyclines. I. Diels-Alder Reaction of 5-Nitronaphthoquinone with Unsymmetrical Butadienes

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概要

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• Diels-Alder reaction of 5-nitro-1,4-naphthoquinone (1) and unsymmetrical butadienes was carried out. Reaction of 1 and 2-methyl-1,3-butadiene gave 1,4,4a, 9a-tetrahydro-2-methyl-5-nitro-anthraquinone (2) and its 3-methyl analogue (3) at the ratio of 9.2 : 1. Reaction of 1 and 1,3-pentadiene gave 1,4,4a, 9a-tetrahydro-1-methyl-8-nitroanthraquinone (8) and its 5-nitro analogue (9) at the ratio of 10 : 7. Their structures have been determined by aromatization to methyl-nitroanthraquinones.

• 公益社団法人日本薬学会の論文
• 1978-08-25

著者

• 織田 範一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 小林 和弘

  名古屋市立大学薬学部

• 植田 泰誠

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 磯雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 小林 和弘

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 植田 泰誠

  Faculty Of Pharmaceutical Sciences Nagoya City University

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