Synthesis of Compounds Related to Antitumor Agents. III. On the Additions of Acyl Halide, Dialkyl Acetylenedicarboxylate and N-Substituted Maleimides to 2,4-Diamino-5-hydroxy-6-methylpyrimidine

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概要

• 論文の詳細を見る

• 2,4-Diamino-5-hydroxy-6-methylpyrimidine (I) was reacted with acyl halides to give pyrimido [5,4-b] [1,4] oxazin-6 (8H)-ones (IIIa, b). Dialkyl acetylenedicarboxylate was made addition with I to afford alkoxycarbonylmethylene-pyrimido [5,4-b] [1,4] oxazines (VI, VII). The configuration of this compound was assumed to be cis from the evidence of building pyridazino or furano ring. Similarly, with maleimide, the adduct (XIV) was obtained and converted to pyrimido [5,4-b] [1,4] oxazines (XV, XXIa-f).

• 社団法人日本薬学会の論文
• 1976-06-25

著者

• 加藤 哲夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 織田 範一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 磯雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

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