Studies on Synthetic Methods for 5-Amino-4 (3H)-pyrimidones. I. A Novel Ring Expansion Reaction of 4-Aminoantipyrines to 5-Amino-4 (3H)-pyrimidones

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概要

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• 4-Anilino (or amino) antipyrines (Ia, b) were transformed into 5-anilino (or amino)-4 (3H)-pyrimidones (IIa, b) in the presence of bases such as sodium hydride, sodium amide, sodium hydroxide, or sodium ethoxide in refluxing xylene. Treatment of IIa with hydrazine hydrate gave 4-anilino-5-hydroxy-3-methyl pyrazole (V). However, the reaction of IIb with hydrazine hydrate gave 3,5-diamino-6-methyl-4 (3H)-pyrimidone (VI) and 4-(5-oxo-3-methyl-pyrazolinyliden) amino-5-hydroxy-3-methyl pyrazole (VII).

• 公益社団法人日本薬学会の論文
• 1980-07-25

著者

• 織田 範一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 植田 泰誠

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 磯雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 植田 泰誠

  Faculty Of Pharmaceutical Sciences Nagoya City University

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