Synthesis of Pyrazolone Derivatives. XXXV. Synthetic and Pharmacological Studies on Some (4S, 7R)-4,7-Methano-1H-indazoles

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概要

• 論文の詳細を見る

• Treatment of (1R, 4S)-2-oxobornaneglyoxylic acid (1) with substituted hydrazines gave (4S, 7R)-1-substituted-4,7-methano-1H-indazole-3-carboxylic acids (2). (4S, 7R)-1-Phenyl-4,7-methanoindazole-3-ol (8) was synthesized by two independent synthetic routes. (4S, 7R)-N-Substituted-4,7-methanoindazole-3-carboxamides (4a, b) were tested on an isolated nerve-muscle preparation of bullfrog. Compound 4b caused marked contracture of the muscle.

• 公益社団法人日本薬学会の論文
• 1979-08-25

著者

• 織田 範一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 磯雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 工藤 佳久

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 工藤 佳久

  Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address) Laboratory Of Pharmacolo

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