Pyridoxine誘導体の合成研究(第1報)5-Substituted-3-(2-methyl-3-hydroxy-5-hydroxymethyl-4-pyridyl)methyl-4-methylthiazoline-2-thione類の合成

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概要

• 論文の詳細を見る

• A series of pyridoxine derivatives having a thiazolidine ring, thiazoline ring, or thiazolium ring at the 4-position were synthesized. Pyridoxal oxime (II), pyridoxal hydrazone (IV), pyridoxalazine (V), and pyridoxal phenylhydrazone (VI) were reduced to pyridoxamine (III) by zinc powder and acetic acid. 3-(3-Hydroxy-5-hydroxymethyl-2-methyl-4-pyridyl) methyl-4-hydroxy-4-methylthiazolidine-2-thione (VIII) was syntheized from chloropropanone, carbon disulfide, and III. Hydrolysis of VIII with 10% hydrochloric acid gave thiazoline-2-thione derivative (IX), whose treatment with hydrogen peroxide in 3% hydrochloric acid afforded thiazolin-2-one derivative (XIV). However, treatment of IX with hydrogen peroxide in 20-30% hydrochloric acid yielded a thiazolium derivative (XV).

• 公益社団法人日本薬学会の論文
• 1975-08-25

著者

• 伊藤 磯雄

  名古屋市立大学薬学部

• 鈴木 健司

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 黒柳 吉雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 黒柳 吉雄

  名古屋市立大学薬学部

• 鈴木 健司

  名古屋市立大学薬学部

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