Synthesis of Pyrazolone Derivatives. XXX. Synthesis of Pyrazolo [3,4-b] [1,4] oxazepines
スポンサーリンク
概要
- 論文の詳細を見る
A novel bicyclic ring, pyrazolo [3,4-b] [1,4] oxazepine was synthesized. The Mannich reaction of 3-hydroxy-5-methyl-1-phenyl pyrazole (I) with p-substituted aniline gave 3-hydroxy-5-methyl-1-phenyl-4-(p-substituted anilino) methyl pyrazoles (II, III, IV, V), which were reacted with chloroacetyl chloride to give 3-methyl-2-phenyl-5-(p-substituted)-phenyl-4,5,6,7-tetrahydro-2H-pyrazolo [3,4-b] [1,4] oxazepin-6-ones (VI, VII, VIII, IX). The reduction of VI, VII, and VIII with lithium aluminum hydride gave 3-methyl-2-phenyl-5-(p-substituted) phenyl-4,5,6,7-tetrahydro-2H-pyrazolo [3,4-b] [1,4] oxazepines (X, XI, XII) and ring-opened products (XIII, XIV, XV).
- 公益社団法人日本薬学会の論文
- 1977-06-25
著者
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伊藤 磯雄
Faculty of Pharmaceutical Sciences, Nagoya City University
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植田 泰誠
Faculty of Pharmaceutical Sciences, Nagoya City University
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伊藤 磯雄
名古屋市立大学薬学部
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伊藤 磯雄
Faculty Of Pharmaceutical Sciences Nagoya City University
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加藤 福実
名古屋市立大学薬学部
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加藤 福実
Faculty of Pharmaceutical Sciences, Nagoya City University
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植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
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