Synthesis of Pyrazolone Derivatives. XVI. Synthesis of Pyrazolo [3,4-c] [1,5] -benzothiazepines and 3- (2-Benzothiazolyl) -3-pyrazolin-5-ones

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概要

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• The Ullmann reaction of 1-phenyl-2-methyl-3- (2-aminophenyl) thiomethyl-4-bromo-3-pyrazolin-5-one (VII) in the solvent of xylene gave 1-methyl-2-phenyl-1,2,3,10-tetra-hydro-4H-pyrazolo [3,4-c] [1,5] benzothiazepin-3-one (XI). However, the same reaction in the solvent of dimethylformamide afforded 1-phenyl-2-methyl-3- (2-benzothiazolyl) -3-pyrazolin-5-one (X). Similarly, 1-phenyl-2-methyl-3- (5-substituted-2-benzothiazolyl) -4-substituted-3-pyrazolin-5-one (XXIV, XXV, XXVI) were synthesized.

• 公益社団法人日本薬学会の論文
• 1970-10-25

著者

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 磯雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 植田 泰誠

  Faculty Of Pharmaceutical Sciences Nagoya City University

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