1,1-Diphenylmethylamine誘導体の薬理学的研究(第1報)N-Alkyl-1,1-diphenylmethylamine誘導体の局所麻酔作用について
スポンサーリンク
概要
- 論文の詳細を見る
1,1-Diphenylmethylamine誘導体の薬理作用として, 局所麻酔作用, 抗histamine作用, 交感神経遮断作用が報告されている.緒方らは構造が比較的簡単な酸素原子を含まないこの種の誘導体の局所麻酔作用と化学構造との関連性を報告している.しかし, この種の誘導体で局所麻酔剤として実用されているものはない.われわれは伊藤らによって合成された数10種の1,1-diphenylmethylamine誘導体のうちから, lidocaineより強い局所麻酔作用を示すN-alkyl-1,1-diphenylmethylamineを見いだした.そこで, この誘導体19種の局所麻酔作用と化学構造との関連性を検討し知見を得たので報告する.
- 公益社団法人日本薬学会の論文
- 1972-06-25
著者
関連論文
- Synthesis of Pyrazolone Derivatives. XXIX. Synthesis of 1,3-Dioxolane-indazole Derivatives
- Synthesis of Compounds related to Antitumor Agents. V. On the Reaction of Aliphatic Carboxylates with 2,4-Diamino-5-hydroxy-6-methylpyrimidine
- Synthesis of Compounds related to Antitumor Agents. VI. The Conversion of 2,4-Dialkoxypyrimidines into N-Dialkyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidines in the Presence of p-Toluenesulfonic Acid Derivatives
- Synthesis of Compounds related to Antitumor Agents. IV. On the Reaction of Aromatic Carboxylates with 2,4-Diamino-5-hydroxy-6-methylpyrimidine
- Synthesis of Compounds Related to Antitumor Agents. III. On the Additions of Acyl Halide, Dialkyl Acetylenedicarboxylate and N-Substituted Maleimides to 2,4-Diamino-5-hydroxy-6-methylpyrimidine
- 抗腫瘍剤関連化合物の合成研究-7-Imidazolo〔1,2-c〕pyrimidine類の合成研究
- Synthesis of Compounds Related to Antitumor Agents. II. Studies on the Synthesis of Oxazolo [4,5-d] pyrimidine Nucleoside Derivatives
- ピラツォロン誘導体の合成研究(第18報) : 1,2,4,5,6,7-Hexahydro-3H-pyrazolo[4,3-c]pyridine類の合成
- ピラゾロン誘導体の合成研究(第42報)2-Methyl-1-phenyl-6,7-dihydro-1H, 5H-pyrazolo[5,1-b][1,3]oxazin-8-ium Bromideの合成と鎮痛作用について
- ピラゾロン誘導体の合成研究(第40報)4-Alkoxyimino(or alkylamino-methylene)-3-methylcarbamoyl-1-methyl(or phenyl)-2-pyrazolin-5-one-の合成と鎮痛作用について
- Synthesis of Pyrazolone Derivatives. XXXIX. Synthesis and Analgesic Activity of Pyrano [2,3-c] pyrazoles
- 抗腫瘍性抗生物質の骨格変換に関する研究(第2報)Naphtho[2,3-g]-quinolineおよびNaphtho[2,3-g]quinoxaline誘導体の合成
- Studies on Synthetic Methods for 5-Amino-4 (3H)-pyrimidones. I. A Novel Ring Expansion Reaction of 4-Aminoantipyrines to 5-Amino-4 (3H)-pyrimidones
- Synthesis of Organometallic Complexes. II. Reaction of (Ferrocenylmethyl) trimethylammonium Iodide with Thiol-Type Nucleophiles
- Synthesis of Polycyclines. II. Synthesis of 12-Hydroxy-5a, 6,-7,8,9,10,11,11a-octahydro-5 (12H)-naphthacenones
- Synthesis of Pyrazolone Derivatives. XXXVI. Synthetic and Pharmacological Studies on (4S, 7R)-4,7-Methano-1H (or 2H)-indazoles and indazolium Compounds
- Synthesis of Pyrazolone Derivatives. XXXV. Synthetic and Pharmacological Studies on Some (4S, 7R)-4,7-Methano-1H-indazoles
- ピラツォロン誘導体の合成研究(第38報)(1R, 4S)-3-Diazobornane-2-oneと活性アセチレンとのCycloadditionにおける[1,5]Sigmatropic転位について
- ピラツォロン誘導体の合成研究(第37報)(4S, 7R)-2-Amino-7,8,8-trimethyl-4,5,6,7-tetrahydro-4,7-methano-2H-indazole関連化合物の合成と薬理
- Synthesis of Polycyclines. I. Diels-Alder Reaction of 5-Nitronaphthoquinone with Unsymmetrical Butadienes
- Synthesis of Pyrazolone Derivatives. XXXI. Asynmetric Synthesis of 3a-Alkyl-3,3a, 4,5,6,7-hexahydro-2H-indazol-3-ones
- Synthesis of Organometallic Complexes. I. Synthesis of Ferrocenylpyrazolone Derivatives
- Synthesis of Pyrazolone Derivatives. XXX. Synthesis of Pyrazolo [3,4-b] [1,4] oxazepines
- Synthetic Studies on Pyridoxine Derivatives. II. Synthesis of 3-(3-Hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl) methyl-4-methyl-5-substitutedthiazoline-2-thiones
- Synthesis of Pyrazolone Derivatives. XXVI. Reaction of 1-Methyl-2-phenyl-1,2,3,10-tetrahydro-4H-benzo [6,7] thiepino [3,4-c] pyrazole-3,4-dione with Dimethyl Acetylenedicarboxylate
- Diphenylmethane誘導体の研究(第4報)Diphenylglycine誘導体の合成
- ピラツォロン誘導体の合成研究(第25報)Thiopyrano[3,4-c]pyrazole誘導体の合成
- 1-(m-chlorophenyl)-3-N, N-dimethylcarbamoyl-5-methoxypyrazole [PZ-177]の一般薬理作用
- Phenethylamineの含イオウ化合物の閉環反応について(第3報)Bischler-Napieralski反応によるN-(Phenylthiomethyl)benzamide類の転位閉環反応
- Pyridoxine誘導体の合成研究(第1報)5-Substituted-3-(2-methyl-3-hydroxy-5-hydroxymethyl-4-pyridyl)methyl-4-methylthiazoline-2-thione類の合成
- Synthesis of N-Methyl-2-[8-(3,4-dimethoxyphenyl)-1,4-dioxaspiro-[4,5] decan-8-yl] ethylamine
- 悪性腫瘍診断薬の研究-1-Ethyl β-Oxo-γ-amino-γ-(3-oxocyclohexane)acetomalonateの合成
- β-ケト酸誘導体の合成研究(第1報) : 2-Bromo-3-oxoglutaric Esterの求核試薬に対する反応性
- Diphenylmethane 誘導体の研究 (第5報) N-Alkylaminopropyl-1,1-diphenyl-methylamine 類およびN-Alkylaminopropyl-1,2-diphenylethylamine 類の合成および薬理作用について
- 1,1-Diphenylmethylamine誘導体の薬理学的研究(第1報)N-Alkyl-1,1-diphenylmethylamine誘導体の局所麻酔作用について
- Diphenylmethane誘導体の研究(第3報)N-Substituted-1-(2,3-dimethoxyphenyl)-1-(2-, 3- or 4-substituted phenyl) methylamine誘導体の合成
- Diphenylmethane誘導体の研究(第2報)N-Substituted-1-(3,4-dimethoxyphenyl)-1-(2-, 3- or 4-substituted phenyl) methylamine誘導体の合成
- Synthesis of 1-(2,3-and 3,4-Dimethoxyphenyl)-1-phenyldimethylamine
- ピラツォロン誘導体の合成研究(第27報) 4-(N-Phenyl)aminopyrazoloneおよび3-(N-Phenyl)aminomethylpyrazolone誘導体の合成
- ピラツォロン誘導体の合成研究-28-ピラツォリン環の3位および4位の反応性について
- Synthesis of Pyrazolone Derivatives. XXIV. Reaction of Pyrazolo [3,4-c]-[1,5] benzothiazepines with Wohl-Ziegler's Reagents
- 抗腫瘍剤関連化合物の合成研究(第1報)Oxazolo[4,5-d]pyrimidine類ならびにPyrimido[5,4-b][1,4]oxazine類の合成研究
- ピラツォロン誘導体の合成研究(第20報)4-Bromo-3-(2-formamidophenyl)-thiomethyl-2-methyl-1-phenyl-3-pyrazolin-5-oneの閉環反応について
- Synthesis of Pyrazolone Derivatives. XVII. Synthesis of a Pyrazolo [3,4-c]-[1] benzoxepin and Pyrazolo [3,4-c] [1,5] benzoxazepines
- Synthesis of Pyrazolone Derivatives. XVI. Synthesis of Pyrazolo [3,4-c] [1,5] -benzothiazepines and 3- (2-Benzothiazolyl) -3-pyrazolin-5-ones
- Synthesis of Pyrazolone Derivatives. XV. Synthesis of 1-Methyl-2-phenyl-1,2,3,10-tetrahydro-4H-pyrazolo [3,4-c] [1] benzothiepin-3,4-dione and Its Derivatives
- Synthesis of Pyrazolone Derivatives. XIV. Synthesis of 3-Mercaptomethyl-2-methyl-1-phenyl-3-pyrazolin-5-one Derivatives
- Synthesis of Pyrazolone Derivatives. XII. Synthesis of 3-Mercaptomethyl-2-methyl-4-substituted-1-phenyl-3-pyrazolin-5-one
- Synthesis of Pyrazolone Derivatives. XI. Synthesis of 6-Substituted 1,2,6,7-Tetrahydro-3H-pyrazolo[4,3-c]pyridine
- Synthesis of Pyrazolone Derivatives. X. Synthesis of 2,4,6-Trioxohexahydro-5-pyrimidinyl Derivatives