Diphenylmethane誘導体の研究(第3報)N-Substituted-1-(2,3-dimethoxyphenyl)-1-(2-, 3- or 4-substituted phenyl) methylamine誘導体の合成
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N-Alkyl-1-(2,3-dimethoxyphenyl)-1-(2-, 3-, or 4-substituted phenyl) methylamines (XI-XLI) were synthesized from 2,3-dimethoxybenzaldehyde (II) using the Grignard reaction, followed by halogenation and amination with various alkylamines. Of the compounds synthesized and tested, XXI, XXII, and XXVII were found to possess a weak antitussive activity, and XI, to XV, XVII, XXI, XXII, and XXVII showed a marked local anesthesic activity.
- 公益社団法人日本薬学会の論文
- 1975-01-25
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