ピラツォロン誘導体の合成研究(第37報)(4S, 7R)-2-Amino-7,8,8-trimethyl-4,5,6,7-tetrahydro-4,7-methano-2H-indazole関連化合物の合成と薬理

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概要

• 論文の詳細を見る

• Oxidation of (4S, 7R)-2-amino-4,7-methano-2H-indazole (2) with Pb (OAc)_4 resulted in ring expansion to give (5S, 8R)-5,8-methano-1,2,3-benzotriazine (5). Irradiation of 5 resulted in photolytic loss of nitrogen to give (1R, 3S)-ethynylcyclopentanecarbonitrile (6) by a radical reaction. Compound 2 was converted to (4S, 7R)-2-substituted-4,7-methano-2H-indazoles (8,10,12,13,14 and 15) and pyridazino [1,6-b] indazoles (9 and 11). Compound 5 showed prominent central nervous system stimulant activity in mice.

• 公益社団法人日本薬学会の論文
• 1979-07-25

著者

• 織田 範一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  名古屋市立大学薬学部

• 永井 慎一

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

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