ナフトキノンを原料とするBenzo[α]phenazine誘導体の合成とその抗菌活性
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概要
- 論文の詳細を見る
Ethyl 5-hydroxybenzo [α] phenazine-6-carboxylates (IIa, b) were prepared by the condensation of ethyl 1,4-dihydro-1,4-dioxo-3-methoxy-2-naphthoate (I) with o-phenylene-diamines. Acylations and alkylations of IIa, b gave the corresponding o-acyl and alkyl compounds (IIIa-k). The reaction of IIa, b with ethanolamine gave β-hydroxyethyl-carboxamides (Va, b). Compound Va was converted into β-chlorinated compound (VIa), whose chlorine was substituted by dialkylamines to give ethylenediamine-type amides (VIIa, b, c). Compounds VIId and VIIe were obtained by the reaction of IIb with dialkylalkylenediamines. Oxidation of IIa, b afforded N-oxides (IXa, b). The antimicrobial activities of all synthetic compounds were tested by paper discagar diffusion assay. Compounds IIId, e, g, VIIa and IXa showed inhibitory activities to T. interdigitale and IXa to C. albicans.
- 公益社団法人日本薬学会の論文
- 1983-02-25
著者
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織田 範一
Faculty of Pharmaceutical Sciences, Nagoya City University
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小林 和弘
名古屋市立大学薬学部
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榊原 仁作
名市大院薬
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榊原 仁作
名古屋市立大学薬学部
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織田 範一
名古屋市立大学薬学部
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織田 範一
Faculty Of Pharmaceutical Sciences Nagoya City University
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