Studies on the Chemical Modification of Monensin. II. : Measurement of Sodium Ion Permeability of Monensylamino Acids Using Sodium-23 Nuclear Magnetic Resonance Spectroscopy
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概要
- 論文の詳細を見る
A technique to assay Na^+ ions in cells is presented. Intracellular and extracellular Na^+ ions in a suspension of guinea pig erythrocytes were conveniently determined by using sodium-23 unclear magnetic resonance (^<23>Na-NMR), in combination with two anionic shift reagents : Dy(TTHA)^<3-> and Dy(PPPi)_2^<7->. Monensin (1), monensylalanine (2b), monensylserine (2c), and monensylphenylalanine (2d) induced large increases of intracellular Na^+ ion concentration ([Na_<in>]), while monensylglycine (2a), monensyltyrosine (2e), monensylaspartic acid (2f), and monensylglutamic acid (2g) showed slight increases. The values of initial increasing rate (V_i) of 2a-g were much smaller than that of 1. This fact was probably due to the lower lipophilicity of 2a-g than 1,because a good correlation was observed between V_i and Rm_<50> values of 1 and 2a-g. This lower lipophilicity is a consequence of conformational differences between 1 and 2a-g.
- 社団法人日本薬学会の論文
- 1989-09-25
著者
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堀田 芳弘
愛知医科大学薬理学教室
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竹谷 和視
愛知医科大学薬理学教室
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植田 泰誠
Faculty of Pharmaceutical Sciences, Nagoya City University
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永井 慎一
Faculty of Pharmaceutical Sciences, Nagoya City University
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中村 明人
Faculty Of Pharmaceutical Sciences
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榊原 仁作
名市大院薬
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榊原 仁作
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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榊原 仁作
Nagoya City Univ. Nagoya Jpn
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永井 慎一
名市大薬
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堀田 芳弘
Department of Pharmacology, Aichi Medical University
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竹谷 和視
Department of Pharmacology, Aichi Medical University
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竹谷 和視
Department Of Pharmacology Aichi Medical University
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植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
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榊原 仁作
Faculty Of Pharmaceutical Sciences Nagoya City University
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