Cardiotonic Flavonoids from Citrus Plants (Rutaceae)
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概要
- 論文の詳細を見る
Two flavonoids, 3,5,6,7,8,3', 4'-heptamethoxyflavone (HEPTA) and natsudaidain isolated from Citrus plants (Rutaceae), produced a positive inotropic effect (PIE) on guinea-pig papillary muscle. Natsudaidain (pD_2 4.98±0.07) was more potent than HEPTA (pD_2 4.33±0.08), but the maximum PIE of HEPTA was greater than that of natsudaidain. The PIE of HEPTA was completely inhibited by reserpinization of the guinea pig, and partially inhibited by metoprolol and carbachol. The carbachol inhibition was omitted by atropine. The mechanism of PIE of HEPTA is accounted for catecholamine release from cardiac tissue.
- 公益社団法人日本薬学会の論文
- 1994-11-15
著者
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竹谷 和視
愛知医科大学薬理学教室
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古川 宏
Faculty of Pharmacy, Meijo University
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古川 宏
Faculty Of Pharmacy Meijo University
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竹谷 和視
Department of Pharmacology, Aichi Medical University
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竹谷 和視
Department Of Pharmacology Aichi Medical University
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糸魚川 政孝
東海学園大学人間健康学部
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糸魚川 政孝
Tokaigakuen Women's College
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