Synthesis of Pyrazolone Derivatives. XXII. Synthesis of Benzo-[4,5] cyclohepta [1,2-c] pyrazole-diones
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概要
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Treatment of methyl 4-benzyl-5-oxo-1-phenyl-3-pyrazoline-3-acetate (7a) with dimethyl sulfate followed by hydrolysis of the resulting methyl 4-benzyl-2-methyl-5-oxo-1-phenyl-3-pyrazoline-3-acetate (9) afforded 4-benzyl-2-methyl-5-oxo-1-phenyl-3-pyrazoline-3-acetic acid (12). 1-Methyl-2-phenyl-3,9-dioxo-1,2,3,4,9,10-hexahydrobenzo [4,5]-cyclohepta [1,2-c] pyrazole (2) was prepared by cyclization of 12 with polyphosphoric acid. The synthesis of 1-methyl-2-phenyl-3,4-dioxo-1,2,3,4,9,10-hexahydrobenzo [4,5] cyclohepta-[1,2-c] pyrazole (3) which is structurally related to 2 was also carried out starting from 4-bromo-3-bromomethyl-2-methyl-1-phenyl-3-pyrazolin-5-one (15).
- 公益社団法人日本薬学会の論文
- 1974-09-25
著者
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伊藤 磯雄
Faculty of Pharmaceutical Sciences, Nagoya City University
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永井 慎一
Faculty of Pharmaceutical Sciences, Nagoya City University
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伊藤 磯雄
Faculty Of Pharmaceutical Sciences Nagoya City University
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