Studies on the chemical Modification of Monensin. III. Synthesis and Sodium Ion transport Activity of macrocylic Monenslamino Acid-1,29-lactones
スポンサーリンク
概要
- 論文の詳細を見る
Monensylglycine (2a) was lactonized to macrocyclic monensylglycine-1,29-lactone (3a) by Corey's mehtod. Lactonization of monensylamino acids (2b-d) to monensylamine acid-1,29-lactones (3b-d) was carried out by utilizing the template effect of K^+ ion. Monobenzyl esters of dicarboxylic monensylamino acids (5e-f) also were lactonized followed by debenzylation to yield carboxylic monensylamino acid-1,29-lactones (3e-f). Sodium ion transport activity of monensin (1) and the lactones (3) was measured in a liquid membra he and in guinea pig erythrocyte membrane. Monensylaspartic acid-1,29-lactone (3d), monensylphenylalanine-1,29-lactone (3c), and monensyltyrosine-1,29-lactone (3d), having smaller Na^+ ion transport activity than 3e, showed weak antibacterial activity, while 3e was inactive in biological tests, probably due to the lower lipophilicity.
- 社団法人日本薬学会の論文
- 1991-07-25
著者
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北川 勲
Faculty of Pharmaceutical Sciences, Osaka University
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渋谷 博孝
Faculty of Pharmaceutical Sciences, Osaka University
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植田 泰誠
Faculty of Pharmaceutical Sciences, Nagoya City University
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永井 慎一
Faculty of Pharmaceutical Sciences, Nagoya City University
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中村 明人
Faculty Of Pharmaceutical Sciences
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榊原 仁作
名市大院薬
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榊原 仁作
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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榊原 仁作
Nagoya City Univ. Nagoya Jpn
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永井 慎一
名市大薬
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村上 啓寿
Faculty Of Pharmaceutical Sciences Osaka University
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北川 勲
Faculty Of Pharmaceutical Sciences Osaka University
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植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
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榊原 仁作
Faculty Of Pharmaceutical Sciences Nagoya City University
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村上 啓寿
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)kyoto Pharmaceutical Univ
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