Marine Natural Products. XXXI. Structure-Activity Correlation of a Potent Cytotoxic Dimeric Macrolide Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei, and Its Isomers

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概要

• 論文の詳細を見る

• Acidic treatment of swinholide A (1), which was characterized as the major cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei, provided several isomeric macrolides having different size of the dilactone ring structure. From the structure-activity correlation viewpoint, the in vitro cytotoxicities and in vivo antitumor activities of these dimeric macrolides, together with two monomeric macrolides which were synthesized from 1,have been examined.

• 社団法人日本薬学会の論文
• 1994-01-15

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 小林 資正

  Faculty of Pharmaceutical Sciences, Osaka University

• 佐々木 琢磨

  金沢大学がん研究所化学療法部

• 佐々木 琢磨

  金沢大学がん研究所

• 佐々木 琢磨

  Cancer Research Institute Kanazawa University

• 佐々木 琢磨

  金沢大学 大学院医学系研究科心肺・総合外科

• 岡本 工

  Faculty of Pharmaceutical Sciences, Osaka University

• 川添 和義

  Faculty of Pharmaceutical Sciences, Osaka University

• 川添 和義

  福山大学

• 北川 勲

  大阪大学

• 佐々木 琢磨

  金沢大 がん研

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• 岡本 工

  Faculty Of Pharmaceutical Sciences Osaka University

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