Marine Natural Products. XXX. Two New 3-Keto-4-methylene Steroids, Theonellasterone and Conicasterone, and a Diels-Alder Type Dimeric Steroid Bistheonellasterone, from the Okinawan Marine Sponge Theonella swinhoei

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概要

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• Two new 3-keto-4-methylene steroids, theonellasterone (3) and conicasterone (4), and a Diels-Alder type dimeric steroid, bistheonellasterone (5), were isolated together with two known 4-methylene sterols, theonellasterol (1) and conicasterol (2), from the Okinawan marine sponge Theonella swinhoei. The structures of these steroids have been elucidated on the basis of chemical and physicochemical evidence. Bistheonellasterone (5) is considered to be biosynthesized through a Diels-Alder cycloaddition of theonellasterone (3) and its Δ^4-isomer. Very interestingly, theonellasterone (3) and conicasterone (4) were seen under an optical microscope as crystals deposited in the tissue of fresh marine sponge.

• 1992-07-25

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 小林 資正

  Faculty of Pharmaceutical Sciences, Osaka University

• 香取 岳人

  Faculty of Pharmaceutical Sciences, Osaka University

• 川添 和義

  Faculty of Pharmaceutical Sciences, Osaka University

• 川添 和義

  福山大学

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 香取 岳人

  大阪大学薬学部

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

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