ESCINS-Ia, Ib, IIa, IIb, AND IIIa, BIOACTIVE TRITERPENE OLIGOGLYCOSIDES FROM THE SEEDS OF AESCULUS HIPPOCASTANUM L. : THEIR INHIBITORY EFFECTS ON ETHANOL ABSORPTION AND HYPOGLYCEMIC ACTIVITY ON GLUCOSE TOLERANCE TEST

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概要

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• Five triterpene oligoglycosides named escins-Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of Aesculus hippocastanum L. and their chemical structures were determined on the basis of chemical and physicochemical evidence. Escins-Ia, Ib, IIa, and IIb were found to exhibit inhibitory effect on ethanol absorption and hypoglycemic activity on oral glucose tolerance test in rats. Among them, escins-IIa and IIb showed the higher activities for both bioassay, while desacylescins-I and II had no activity.

• 社団法人日本薬学会の論文
• 1994-06-15

著者

• 原田 英美子

  大阪大 薬

• 原田 英美子

  奈良先端科学技術大学院大学遺伝子教育研究センター

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 吉川 雅之

  Kyoto Pharmaceutical Univ.

• 山原 條二

  京都薬科大学生薬学教室

• 北川 勲

  大阪大学

• 山原 條二

  Kyoto Pharmaceutical University

• 村上 啓寿

  Kyoto Pharmaceutical University

• 原田 英美子

  Kyoto Pharmaceutical University

• 村上 敏之

  Kyoto Pharmaceutical University

• 松田 久司

  Kyoto Pharmaceutical University

• 山原 条二

  京都薬大

• 割石 紀子

  森下仁丹 (株) 研究開発部

• 割石 紀子

  Kyoto Pharmaceutical University

• 山原 絛二

  Kyoto Pharmaceutical University

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 松田 久司

  Kyoto Pharmaceutical Univ.

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