ARAGUSPONGINES B, C, D, E, F, G, H, AND J, NEW VASODILATIVE BIS-1-OXAQUINOLIZIDINE ALKALOIDS FROM AN OKINAWAN MARINE SPONGE, XESTOSPONGIA SP.

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概要

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• Nine new vasodilative alkaloids, araguspongines A, B (1__〜), C(2__〜), D(3__〜), E(4__〜), F(5__〜), G(6__〜), H(7__〜), and J(8__〜), were isolated from an Okinawan marine sponge, Xestospongia sp. On the basis of chemical and physicochemical evidence, the absolute stereostructures of araguspongines B, D, E, F, G, H, and J were determined respectively as 1__〜, 3__〜, 4__〜, 5__〜, 6__〜, 7__〜, 8__〜, and the relative stereostructure of araguspongine C was determined as 2__〜having two 1-oxaquinolizidine moieties. Araguspongines B, D, and E each comprised a pair of the enantiomers <1a>___〜 and <2b>___〜, <3a>___〜 and <3b>___〜, and <4a>___〜 and &<4b>___〜, respectively.

• 1989-06-25

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 小林 資正

  Faculty of Pharmaceutical Sciences, Osaka University

• 川添 和義

  Faculty of Pharmaceutical Sciences, Osaka University

• 川添 和義

  福山大学

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

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