DEHATRINE, AN ANTIMALARIAL BISBENZYLISOQUINOLINE ALKALOID FROM THE INDONESIAN MEDICINAL PLANT BEILSCHMIEDIA MADANG, ISOLATED AS A MIXTURE OF TWO ROTATIONAL ISOMERS

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概要

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• Through bioassay-guided separations of the chemical constituents of the Indonesian medicinal plant Beilschmiedia madang BL. a bisbenzylisoquinoline alkaloid was obtained as the major antimalarial principle. The physicochemical properties of the alkaloid were consistent with the proposed structure of dehatrine (1). However, the alkaloid isolated by us was shown to be a mixture of two rotational isomers. The X-ray crystallographic analysis of 1 has shown that two rotamers are incorporated in a single crystal in 1 : 1 ratio. The complex NMR spectrum of 1 has also been defined as a mixture of two rotamers by extensive use of 2D (COSY and COLOC) techniques. Dehatrine (1) has been shown to significantly inhibit the growth of cultured Plasmodium falciparum K1 strain (cholorquine resistant) with similar activity to quinine.

• 社団法人日本薬学会の論文
• 1993-05-15

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 土井 光暢

  大阪薬大

• 石田 寿昌

  大阪薬大

• 渋谷 博孝

  Faculty of Pharmaceutical Sciences, Osaka University

• 石田 寿昌

  大阪薬科大学

• 石田 寿昌

  Osaka University of Pharmaceutical Sciences

• 堀 一之

  大阪大学薬学部

• 堀 一之

  Faculty of Pharmaceutical Sciences, Osaka University

• 土井 充暢

  Osaka University of Pharmaceutical Sciences

• 井上 正敏

  Osaka University of Pharmaceutical Sciences

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 井上 正敏

  大阪薬大

• 皆川 和之

  Faculty of Pharmaceutical Sciences, Osaka University

• 張 如松

  Faculty of Pharmaceutical Sciences, Osaka University

• 土井 光暢

  Osaka University of Pharmaceutical Sciences

• 木村 政継

  Medical School, Osaka City University

• UJI Tahan

  Herbarium Bogoriense, Pusat Penelitian dan Pengembangan Biologi-LIPI

• 張 如松

  大阪大学薬学部

• 皆川 和之

  大阪大学薬学部

• 石田 寿晶

  大阪薬科大学

• 木村 政継

  大阪市立大学医学部

• Doi Mitsunobu

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• 井上 正敏

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Uji T

  Herbarium Bogoriense Research And Development Centre For Biology Lipi

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