Marine Natural Products. XXII. : The Absolute Stereostructure of Swinholide A, a Potent Cytotoxic Dimeric Macrolide from the Okinawan Marine Sponge Theonella swinhoei

スポンサーリンク

概要

• 論文の詳細を見る

• A potent cytotoxic dimeric macrolide, swinholide A (1), was isolated from the Okinawan marine sponge Theonella swinhoei. The absolute stereostructure of 1,having a dimeric dilactone structure with a 44-membered ring, has been determined on the basis of its chemical behavior and an X-ray crystallographic analysis.

• 社団法人日本薬学会の論文
• 1990-09-25

著者

• 田中 淳一

  琉球大理

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 小林 資正

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 淳一

  Department of Marine Sciences, University of Ryukyus

• 香取 岳人

  Faculty of Pharmaceutical Sciences, Osaka University

• 松浦 美紀

  Faculty of Pharmaceutical Sciences, Osaka University

• 山下 恵

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 淳一

  琉球大・理・海洋自然科学

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 山下 恵

  Faculty Of Pharmaceutical Sciences Osaka University

• 香取 岳人

  大阪大学薬学部

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• 田中 淳一

  琉球・理・海洋

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• 田中 淳一

  琉球大学理学部

• Tanaka J

  Department Of Chemistry Biology And Marine Science University Of The Ryukyus

• 松浦 美紀

  Faculty Of Pharmaceutical Sciences Osaka University

• Tanaka Junichi

  Department Of Chemistry Biology And Marine Science University Of The Ryukyus

関連論文

• 2Dp17 蛍光消光現象を利用したC型肝炎ウイルス由来ヘリカーゼ活性阻害剤の探索(酵素学・酵素工学,一般講演)
• Structures of Echinoside A and B, Two Antifungal Oligoglycosides from the Sea Cucumber Actinopyga echinites (JAEGER)
• 91(P-16) アクチンを標的とする海産マクロライド類とデプシペプチド類の構造と活性(ポスター発表の部)
• 60(P-37) インドネシア産海綿Theonella swinhoeiから得られた環状ペプチド類(ポスター発表の部)
• Marine Natural Products. XXIV. : The Absolute Stereostructure of Misakinolide A, a Potent Cytotoxic Dimeric Macrolide from an Okinawan Marine Sponge Theonella sp.
• Marine Natural Products. XXIII. : Three New Cytotoxic Dimeric Macrolides, Swinholides B and C and Isoswinholide A, Congeners of Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei
• 17 Theonella属海綿の産生する二量体マクロリド類の化学構造と抗腫瘍活性(口頭発表の部)
• Marine Natural Products. XXII. : The Absolute Stereostructure of Swinholide A, a Potent Cytotoxic Dimeric Macrolide from the Okinawan Marine Sponge Theonella swinhoei
• 501 合成樹脂担体充填型界面バイオリアクター : 酢酸2-エチルヘキシルの加水分解への適用
• STRUCTURE OF THEONELLAPEPTOLIDE ID, A NEW BIOACTIVE PEPTOLIDE FROM AN OKIKAWAN MARINE SPONGE, THEONELLA SP. (THEONELLIAE)
• Chemical Transformation of Terpenoids. X. Ionophoretic Activities of Macrocyclic Lactone Epoxides Synthesized from Geraniol
• Chemical Transformation of Terpenoids. IX. Ionophoretic Activities of Macrocyclic Lactone Epoxides Synthesized from E, E-Farnesol
• Syntheses of a Glycerophospholipid, C16-Platelet Activating Factor and a Palmitoyl Analogue of M-5,an Anti-inflammatory Glyceroglycolipid
• Syntheses of Two Pairs of Enantiomeric C18-Sphingosines and a Palmitoyl Analogue of Gaucher Spleen Glucocerebroside
• 2Ga05 蛍光消光現象を利用したC型肝炎ウイルス由来ヘリケース活性阻害剤の探索(酵素学,酵素工学,タンパク質工学,一般講演)
• Marine Natural Products. XXXII. Absolute Configurations of C-4 of the Manoalide Family, Biologically Active Sesterterpenes from the Marine Sponge Hyrtions erecta
• Marine Natural Products. XXXI. Structure-Activity Correlation of a Potent Cytotoxic Dimeric Macrolide Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei, and Its Isomers
• ALTOHYRTINS B AND C AND 5-DESACETYLALTOHYRTIN A, POTENT CYTOTOXIC MACROLIDE CONGENERS OF ALTOHYRTIN A, FROM THE OKINAWAN MARINE SPONGE HYRTIOS ALTUM
• Indonesian Medicinal Plants. XI. Chemical Structures of Caesaldekarins a and b, Two New Cassane-Type Furanoditerpenes from the Roots of Caesalpinia major (Fabaceae)
• A NEW METHOD FOR MEASURING IONOPHORETIC ACTIVITY USING A GLASS-CELL APPARATUS EQUIPPED WITH ARTIFICIAL MEMBRANES
• ESCINS-Ia, Ib, IIa, IIb, AND IIIa, BIOACTIVE TRITERPENE OLIGOGLYCOSIDES FROM THE SEEDS OF AESCULUS HIPPOCASTANUM L. : THEIR INHIBITORY EFFECTS ON ETHANOL ABSORPTION AND HYPOGLYCEMIC ACTIVITY ON GLUCOSE TOLERANCE TEST
• Chemical Studies of Chinese Licorice-Roots. I. Elucidation of Five New Flavonoid Constituents from the Roots of Glycyrrhiza glabra L. Collected in Xinjiang
• ABSOLUTE STEREOSTRUCTURES OF PAEONISOTHUJONE, A NOVEL SKELETAL MONOTERPENE KETONE, AND DEOXYPAEONISUFFRONE, AND ISOPAEONISUFFRAL, TWO NEW MONOTERPENES, FROM MOUTAN CORTEX
• ABSOLUTE STEREOSTRUCTURES OF PAEONISUFFRONE AND PAEONISUFFRAL, TWO NEW LABILE MONOTERPENES, FROM CHINESE MOUTAN CORTEX
• Histochemistry. VI. Tocopherols and Isoflavones in Soybeans (Glycine max MERRILL, Seeds)
• Histochemistry. V. Soyasaponins in Soybeans (Glycine max MERRILL, Seeds)
• 2P-1164 可食農水産植物由来NF-κB活性制御因子の単離と評価(4b食品科学,食品工学,一般講演,醸造・食品工学,伝統の技と先端科学技術の融合)
• Indonesian Medicinal Plants. X. Chemical Structures of Four New Triterpene-Glycosides, Gongganosides D, E, F, and G, and Two Secoiridoid-Glucosides from the Bark of Bhesa paniculata (Celastraceae)
• Indonesian Medicinal Plants. IX. Chemical Structures of Gongganosides A, B, and C, Three New Quinovic Acid Glycosides from the Bark of Bhesa paniculata (Celastraceae)
• Marine Natural Products. XXX. Two New 3-Keto-4-methylene Steroids, Theonellasterone and Conicasterone, and a Diels-Alder Type Dimeric Steroid Bistheonellasterone, from the Okinawan Marine Sponge Theonella swinhoei
• Marine Natural Products. XXIX. Heterosigma-glycolipids I, II, III, and IV, Four Diacylglyceroglycolipids Possessing ω3-Polyunsaturated Fatty Acid Residues, from the Raphidopycean Dinoflagellate Heterosigma akashiwo
• ARAGUSPONGINES B, C, D, E, F, G, H, AND J, NEW VASODILATIVE BIS-1-OXAQUINOLIZIDINE ALKALOIDS FROM AN OKINAWAN MARINE SPONGE, XESTOSPONGIA SP.
• Chemical Transformation of Terpenoids. VI. Syntheses of Chiral Segments, Key Building-Blocks for the Left Half of Taxane-Type Diterpenoids
• Chemical Transformation of Terpenoids. IV. Acid Treatment of (3R)-1-Vinyl-, (3R)-1-Hydroxypropenyl-, and (3R)-1-Epoxyethyl-5-methoxy-1,2,2-trimethylcyclopentane Derivatives : Ring Enlargement Reactions and Successive Migrations of Methyl Residues
• Chemical Transformation of Terpenoids. III. Syntheses of (3R)-1-Vinyl-, (3R)-1-Hydroxypropenyl-, and (3R)-1-Epoxyethyl-5-methoxy-1,2,2-trimethylcyclopentane Derivatives from d-Camphor via 5-Oxo-d-bornyl Acetate
• Chemical Transformation of Terpenoids. II. Acid Treatment of (3S)-1-Vinyl-, (3S)-1-Hydroxypropenyl-, and (3S)-1-Epoxyethyl-1,2,2-trimethylcyclopentane Derivatives : Ring Enlargement Reactions and Successive Migrations of Methyl Residues
• Chemical Transformation of Terpenoids. I. Syntheses of (3S)-1-Vinyl-, (3S)-1-Hydroxypropenyl-, and (3S)-1-Epoxyethyl-1,2,2-trimethylcyclopentane Derivatives from d-Camphor via d-Camphoric Acid
• Biogenetically Patterned Transformation of Eudesmanolide to Eremophilanolide. V. Studies on Stereochemical Factors for Favorable Conversion of 5α, 6α-Epoxy-eudesman-8β, 12-olide leading to Eremophilane-type Derivatives
• On the Constituents of Picrorhiza kurrooa. (1). The Structure of Picroside I, a Bitter Principle of the Subterranean Part
• Saponin and Sapogenol. IV. Seeds Sapogenols of Aesculus turbinata BLUME. On the Configuration of Hydroxyl Functions in Ring E of Aescigenin, Protoaescigenin, and Isoaescigenin in Relation to Barringtogenol C and Theasapogenol A
• Saponin and Sapogenol. III. Seeds Sapogenols of Thea sinensis L. (3). Theasapogenol E and Minor Sapogenols
• Saponin and Sapogenol. II. Seeds Sapogenols of Thea sinensis L. (2). Theasapogenol A
• Saponin and Sapogenol. I. Seeds Sapogenols of Thea sinensis L. (1). Barringtogenol C (=Theasapogenol B)
• Comparative Study on the Sapogenin Constituents of Five Primulaceous Plants
• On the Iridoid Constituent isolated from the Roots of Scrophularia buergeriana MIQ.
• 762 プロピオン酸菌を用いた新規培養システムによるビタミンB_の生産
• Marine Natural Products. XXXIV. Trisindoline, a New Antibiotic Indole Trimer, Produced by a Bacterium of Vibrio sp. Separated from the Marine Sponge Hyrtios altum
• Indonesian Medicinal Plants. VI. On the Chemical Constituents of the Bark of Picrasma javanica BL. (Simaroubaceae) from Flores Island. Absolute Stereostructures of Picrajavanins A and B
• Marine Natural Products. X. Pharmacologically Active Glycolipids from the Okinawan Marine Sponge Phyllospongia foliascens (PALLAS)
• Foliaspongin, an Antiinflammatory Bishomosesterterpene from the Marine Sponge Phyllospongia foliascens (PALLAS)
• Studies on the chemical Modification of Monensin. III. Synthesis and Sodium Ion transport Activity of macrocylic Monenslamino Acid-1,29-lactones
• DEHATRINE, AN ANTIMALARIAL BISBENZYLISOQUINOLINE ALKALOID FROM THE INDONESIAN MEDICINAL PLANT BEILSCHMIEDIA MADANG, ISOLATED AS A MIXTURE OF TWO ROTATIONAL ISOMERS
• Solubilization of Saponins of Bupleuri Radix with Ginseng Saponins : Effect of Malonyl-ginsenosides on Water Solubility of Saikosaponin-b
• Indonesian Medicinal Plants. V. Chemical Structures of Calotroposides C, D, E, F, and G, Five Additional New Oxypregnane-Oligoglycosides from the Root of Calotropis gigantea (Asclepiadaceae)
• Indonesian Medicinal Plants. IV. On the Constituents of the Bark of Fagara rhetza (Rutaceae). (2). Lignan Glycosides and Two Apioglucosides
• Indonesian Medicinal Plants. III. On the Constituents of the Bark of Fagara rhetza (Rutaceae).(1) : Alkaloids, Phenylpropanoids, and Acid Amide
• Indonesian Medicinal Plants. II. Chemical Structures of Pongapinones A and B, Two New Phenylpropanoids from the Bark of Pongamia pinnata (Papilionaceae)
• Indonesian Medicinal Plants. I. Chemical Structures of Calotroposides A and B, Two New Oxypregnane-Oligoglycosides from the Root of Calotropis gigantea (Asclepiadaceae)
• Three New Oleanene Glycosides from Sophora flavescens
• GALLOYL-OXYPAEONIFLORIN, SUFFRUTICOSIDES A, B, C, AND D, FIVE NEW ANTIOXIDATIVE GLYCOSIDES, AND SUFFRUTICOSIDE E, A PAEONOL GLYCOSIDE, FROM CHINESE MOUTAN CORTEX
• Asernestioside C, a New Minor Saponin from the Roots of Astragalus ernestii COMB.; First Example of Negative Nuclear Overhauser Effect in the Saponins
• HETEROSIGMA-GLYCOLIPIDS I AND II, TWO NEW GALACTOLIPIDS CONTAINING OCTADECATETRAENOYL AND EICOSAPENTAENOYL RESIDUES, FROM A RAPHIDOPHYTE DINOFLAGELLATE HETEROSIGMA SP.
• Marine Natural Products. XX. : Bioactive Scalarane-Type Bishomosesterterpenes from the Okinawan Marine Sponge Phyllospongia foliascens
• Marine Natural Products. XIX. : Pervicosides A, B, and C, Lanostane-Type Triterpene-Oligoglycoside Sulfates from the Sea Cucumber Holothuria pervicax
• Marine Natural Products. XVIII. : Four Lanostane-Type Triterpene Oligoglycosides, Bivittosides A, B, C, and D, from the Okinawan Sea Cucumber Bohadschia bivittata MITSUKURI
• Marine Natural Products. XVII. Nephtheoxydiol, a New Cytotoxic Hydroperoxy-Germacrane Sesquiterpene, and Related Sesquiterpenoids from an Okinawan Soft Coral of Nephthea sp. (Nephtheidae)(Organic,Chemical)
• Marine Natural Products. XVI. : Structures of Five New Diterpenes from an Okinawan Soft Coral of Xenia sp. (Xeniidae)
• KERICEMBRENOLIDES A, B, C, D, AND E, FIVE NEW CYTOTOXIC CEMBRENOLIDES FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
• Marine Natural Products. XIV. Structures of Echinosides A and B, Antifungal Lanostane-Oligosides from the Sea Cucumber Actinopyga echinites (JAEGER)
• XENIOLONE AND ISOXENIOLONE TWO NEW DITERPENES HAVING A PERHYDROAZULENE SKELETON FROM AN OKINAWAN SOFT CORAL OF XENIA SP.
• HALENAQUINOL AND HALENAQUINOL SULFATE, PENTACYCLIC HYDROQUINONES FROM THE OKINAWAN MARINE SPONGE XESTOSPONGIA SAPRA
• CLAVUKERIN C, A NEW TRINOR-GUAIANE SESQUITERPENE HAVING A HYDROPEROXY FUNCTION, FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
• Marine Natural Products. XII. On the Chemical Constituents of the Okinawan Marine Sponge Hymeniacidon aldis
• CLAVUKERIN A, A NEW TRINOR-GUAIANE SESQUITERPENE FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
• ABSOLUTE STEREOSTRUCTURES OF CLAVIRIDENONE-A, -B, -C, AND -D FOUR PROSTANOIDS FROM THE OKINAWAN SOFT CORAL CLAVULARIA VIRIDIS
• THREE NEW ent-VALERENANE SESQUITERPENES FROM AN OKINAWAN SOFT CORAL
• Marine Natural Products. IX. Structural Elucidation of Triterpenoidal Oligoglycosides from the Bahamean Sea Cucumber Actinopyga agassizi SELENKA
• The Structures of Six Antifungal Oligoglycosides, Stichlorosides A_1,A_2,B_1,B_2,C_1,and C_2,from the Sea Cucumber Stichopus Chloronotus (BRANDT)
• Marine Natural Products. VIII. Bioactive Triterpene-Oligoglycosides from the Sea Cucumber Holothuria leucospilota BRANDT (2). Structure of Holethurin A
• Marine Natural Products. VII. Bioactive Triterpene-Oligoglycosides from the Sea Cucumber Holothuria leucospilota BRANDT (1). Structure of Holothurin B
• Lichen Triterpenoids. IV. The Structures of Leucotylic Acid and Methyl Isoleucotylate, an Acid-induced Isomer of Methyl Leucotylate
• On the Triterpenic Constituents of a Lichen, Parmelia entotheiochroa HUE.; Zeorin, Leucotylin, Leucotylic Acid, and Five New Related Triterpenoids
• Marine Natural Products. XXVI. Biologically Active Tridecapeptide Lactones from the Okinawan Marine Sponge Theonella swinhoei(Theonellidae).(2).Structures of Theonellapeptolides Ia, Ib, Ic, and Ie
• Saponin and Sapogenol. XXX. Furostanol Glycosides from Metanarthecium luteo-viride MAXIM. : Bisdesmosides of Furometagenin and Furometanarthogenin
• Saponin and Sapogenol. XXII. Structure of Spergulatriol, A New Bisnorhopane-type Genuine Sapogenol of Isoanhydrospergulatriol, from the Root of Mollugo spergula L.
• On the Constituents of Seeds of Horsfieldia iryaghedhi WARB. I
• Lichen Triterpenoids. III. The Final Conclusion on the Stereostructure of Zeorin and Its Correlation with Leucotylin. The Structure of Isoleucotylin
• Lichen Triterpenoids. II. The Stereostructure of Zeorin
• Lichen Triterpenoids. I. The Structure of Leucotylin
• Anomalous Photoemission under the Influence of a Charged Substrance in Low-Frequency Parallel-Plates Discharge in N_2 Gas
• Asymmetrical Emission Profiles from Low-Frequency Discharges in SF_6 and in N_2 Gases in a Planar Diode with a Si-Wafer
• P-441 NEW BIOACTIVE POLYBROMINATED DIPHENYL ETHERS FROM THE INDONESIAN MARINE SPONGE, DYSIDEA SP.
• P-163 HIPPURISTANOL : A SELECTIVE INHIBITOR OF RNA HELICASE eIF4A
• 海洋生物由来のアクチンを標的とする多様な分子
• 糖尿病患者はインスリン注射から逃れられるか
• Antioxidative Compounds Isolated from Kokuto, Non-centrifugal Cane Sugar
• Umabanol, a New Tetracyclic Diterpene from a Marine Sponge
• P-315 HOW SOME NUDIBRANCHS CAN TOLERATE TOXICITY OF ACTIN-TARGETING MOLECULES?
• 2Bp15 海洋生物抽出物より取得したcholesterol sulfateによるC型肝炎ウイルスNS3 helicase阻害作用(バイオマス・資源・エネルギー工学/生合成・天然物化学,一般講演)
• 30 (-)-Zampanolideの全合成(口頭発表の部)

もっと見る 閉じる

スポンサーリンク