Chemical Transformation of Terpenoids. IX. Ionophoretic Activities of Macrocyclic Lactone Epoxides Synthesized from E, E-Farnesol
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概要
- 論文の詳細を見る
Two diastereomeric macrocyclic lactone epoxides, i.e., a 13-membered-ring monomeric lactone diepoxide (FL_1,E_2,7) and a 26-membered-ring dimeric lactone tetraepoxide (FL_2E_4,8), were synthesized from E, E-farnesol by employing a new lactonization reaction with sodium hydride. Examinations by using a W-07 apparatus (liquid-membrane type) and by means of the human erythrocyte membrane method, have shown that FL_2E_4 (8) exhibits not only ion-transport activity for K^+ ion but also ion-permeation activity for K^+ ion across the human erythrocyte membrane, while FL_1E_2 (7) decreases the Na^+ ion concentration inside human erythrocytes. Furthermore, we studied the dependence of the ionophoretic activities for K^+ ion upon the epoxide configurations by using six distereomers of FL_2E_4 (8).
- 社団法人日本薬学会の論文
- 1993-12-15
著者
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北川 勲
Faculty of Pharmaceutical Sciences, Osaka University
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成田 憲彦
大阪大学薬学部
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石田 寿昌
大阪薬大
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石田 寿昌
大阪薬科大学
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大橋 一慶
福山大学
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大橋 一慶
Faculty of Science, Shizuoka University
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成田 憲彦
Faculty of Pharmaceutical Sciences, Osaka University
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石田 寿昌
Osaka University of Pharmaceutical Sciences
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堀 一之
大阪大学薬学部
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川西 博之
大阪大学薬学部
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澁谷 博孝
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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堀 一之
Faculty of Pharmaceutical Sciences, Osaka University
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川西 博之
Faculty of Pharmaceutical Sciences, Osaka University
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北川 勲
Faculty Of Pharmaceutical Sciences Osaka University
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石田 寿晶
大阪薬科大学
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