Synthesis of Pyrazolone Derivatives. XXIII. Benzo[5,6]cyclohepta[1,2-c]pyrazole-3,10-dione and Related Compounds
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概要
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Syntheses of 1-methyl-2-phenyl-1,2,3,4,5-pentahydro-10H-benzo[5,6]cyclohepta[1,2-c]pyrazole-3,10-dione (3a) and its aminoalkylidene derivatives (3b-d) were investigated. Treatment of 3a with N-bromosuccinimide gave 4 (5)-bromo-1-methyl-2-phenyl-1,2,3-trihydro-10H-benzo[5,6]cyclohepta[1,2-c]pyrazole-3,10-dione (13), while reaction of 3a with N-chlorosuccinimide produced 2-phenyl-2,3,3a, 4,5-pentahydro-10H-benzo[5,6]cyclohepta[1,2-c]pyrazole-3,10-dione (15). Dehydrogenation of 3a at 310°with palladium on carbon catalyst afforded 1-methyl-2-phenyl-1,2,3-trihydro-10H-benzo[5,6]cyclohepta[1,2-c]pyrazole-3,10-dione (18) in a trace.
- 公益社団法人日本薬学会の論文
- 1974-12-25
著者
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伊藤 磯雄
Faculty of Pharmaceutical Sciences, Nagoya City University
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永井 慎一
Faculty of Pharmaceutical Sciences, Nagoya City University
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伊藤 磯雄
Faculty Of Pharmaceutical Sciences Nagoya City University
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